Detailed information of TA system TA021298

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 2132292..2132824
• Replicon: chromosome
• Accession: NC_007512
• Organism: Chlorobium luteolum DSM 273

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: Q3B1M0
• Locus tag: PLUT_RS09895
• Protein ID: WP_011358631.1
• Coordinates: 2132501..2132824 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: PLUT_RS09890
• Protein ID: WP_041464212.1
• Coordinates: 2132292..2132504 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLUT_RS09870	2127648..2129453	+	1806	WP_011358626.1	phosphoenolpyruvate--protein phosphotransferase	-
PLUT_RS09875	2129870..2130112	+	243	WP_011358627.1	helix-turn-helix domain-containing protein	-
PLUT_RS09880	2130112..2131437	+	1326	WP_011358628.1	type II toxin-antitoxin system HipA family toxin	-
PLUT_RS11815	2131498..2131902	+	405	WP_011358629.1	hypothetical protein	-
PLUT_RS09890	2132292..2132504	+	213	WP_041464212.1	antitoxin MazE family protein	Antitoxin
PLUT_RS09895	2132501..2132824	+	324	WP_011358631.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
PLUT_RS11820	2133150..2133398	-	249	WP_157858189.1	hypothetical protein	-
PLUT_RS09900	2133577..2133876	-	300	WP_157858190.1	hypothetical protein	-
PLUT_RS09905	2133863..2135032	-	1170	WP_011358633.1	ATP-binding protein	-
PLUT_RS11610	2135309..2135608	+	300	Protein_1961	HipA domain-containing protein	-
PLUT_RS09915	2135630..2137735	-	2106	WP_011358634.1	peptidyl-prolyl cis-trans isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-105)

Antitoxin

• Antitoxin MazE-like (5-68)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11673.58 Da
• Isoelectric Point: 8.6383

>T21298 WP_011358631.1 NC_007512:2132501-2132824 [Pelodictyon luteolum DSM 273]
MKRGELVSIALSGDYGKPRPALVVQSDFFSEHPSVTVLPVTSELRSAPLFRIEIPPTADNNLKKLSQVMVDKIQTVPSEK
VGPVFGRLDDTSLLAINRALALWLGFA

Nucleotide

• Length: 324 bp

>T21298 NC_007512:2132501-2132824 [Pelodictyon luteolum DSM 273]
ATGAAGCGGGGCGAGCTCGTCTCCATTGCATTATCAGGCGACTACGGCAAGCCACGCCCTGCCCTCGTCGTTCAGTCTGA
TTTCTTTTCTGAACATCCTTCTGTGACGGTGCTGCCCGTGACCAGCGAACTTCGTTCAGCGCCGTTGTTTCGCATTGAGA
TTCCTCCGACGGCAGACAACAACCTGAAAAAGCTTTCCCAAGTGATGGTGGATAAAATCCAGACCGTCCCTTCTGAAAAG
GTGGGGCCTGTTTTTGGACGGCTCGATGATACAAGCTTACTCGCCATTAACCGGGCATTGGCTTTGTGGCTGGGGTTTGC
GTAG

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 8025.27 Da
• Isoelectric Point: 10.7990

>AT21298 WP_041464212.1 NC_007512:2132292-2132504 [Pelodictyon luteolum DSM 273]
MAGVAERVQKYRAGLRKAGMRPLQIWVPDTRRAGFAAECRRQSALLKKDHQEKEVLQFLEKAADREGWTA

Nucleotide

• Length: 213 bp

>AT21298 NC_007512:2132292-2132504 [Pelodictyon luteolum DSM 273]
ATGGCGGGGGTAGCCGAAAGAGTTCAAAAGTACAGGGCGGGCTTACGCAAGGCCGGGATGCGCCCGTTGCAAATATGGGT
TCCCGATACCCGGCGGGCAGGGTTCGCGGCGGAGTGCAGGCGGCAATCGGCCCTTTTGAAAAAAGATCATCAGGAAAAGG
AAGTCCTGCAGTTTCTGGAAAAGGCCGCAGACCGTGAAGGGTGGACGGCATGA

Structures

Toxin

• AlphaFold DB: Q3B1M0