Detailed information of TA system TA212973

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 31221..31765
• Replicon: plasmid unnamed2
• Accession: NZ_CP081675
• Organism: Mycolicibacterium farcinogenes strain BKK/CU-MFGFA-001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K6L26_RS31180
• Protein ID: WP_206477742.1
• Coordinates: 31221..31499 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K6L26_RS31185
• Protein ID: WP_206477743.1
• Coordinates: 31496..31765 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6L26_RS31165 (K6L26_31165)	27901..29307	+	1407	WP_016341434.1	IS1380 family transposase	-
K6L26_RS31170 (K6L26_31170)	29524..29865	-	342	WP_206477890.1	hypothetical protein	-
K6L26_RS31175 (K6L26_31175)	30517..31014	-	498	WP_206477920.1	hypothetical protein	-
K6L26_RS31180 (K6L26_31180)	31221..31499	-	279	WP_206477742.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K6L26_RS31185 (K6L26_31185)	31496..31765	-	270	WP_206477743.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K6L26_RS31190 (K6L26_31190)	31928..33133	+	1206	WP_206477746.1	XRE family transcriptional regulator	-
K6L26_RS31195 (K6L26_31195)	33297..34163	-	867	WP_206477747.1	hypothetical protein	-
K6L26_RS31200 (K6L26_31200)	34156..35046	-	891	WP_221853662.1	ParA family protein	-
K6L26_RS31205 (K6L26_31205)	35850..36575	+	726	WP_206477748.1	DUF2637 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..91789	91789
	-	flank	IS/Tn	-	-	27901..29307	1406

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10561.18 Da
• Isoelectric Point: 10.8916

>T212973 WP_206477742.1 NZ_CP081675:c31499-31221 [Mycolicibacterium farcinogenes]
VSNDQPWAVRLAPSAVRALDRLPHKVAAAIVEFITATLPTDPYRMSKPLRHELEGWRVARRGDYRVTFRILDDAHALLIG
RVEHRAHIYRPS

Nucleotide

• Length: 279 bp

>T212973 NZ_CP107418:67714-68130 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9647.81 Da
• Isoelectric Point: 4.8261

>AT212973 WP_206477743.1 NZ_CP081675:c31765-31496 [Mycolicibacterium farcinogenes]
MKTVPLSEAKDKLSALVDEADSTHEIIRITRHGRAAAVLMSADDLDSLNETLHALRTPGLVDELNQADADYAAGKTITGE
DLRKRYGLS

Nucleotide

• Length: 270 bp

>AT212973 NZ_CP107418:67487-67717 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA