Detailed information of TA system TA212971

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1523465..1524097
• Replicon: chromosome
• Accession: NZ_CP081673
• Organism: Mycolicibacterium farcinogenes strain BKK/CU-MFGFA-001

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: K6L26_RS07105
• Protein ID: WP_019347713.1
• Coordinates: 1523648..1524097 (+)
• Length: 150 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: A0A1A1W632
• Locus tag: K6L26_RS07100
• Protein ID: WP_064896898.1
• Coordinates: 1523465..1523644 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6L26_RS07085 (K6L26_07085)	1518996..1519730	+	735	WP_036392158.1	enoyl-CoA hydratase	-
K6L26_RS07090 (K6L26_07090)	1519732..1520847	+	1116	WP_047038655.1	MBL fold metallo-hydrolase	-
K6L26_RS07095 (K6L26_07095)	1520914..1523406	+	2493	WP_064896900.1	cation-translocating P-type ATPase	-
K6L26_RS07100 (K6L26_07100)	1523465..1523644	+	180	WP_064896898.1	antitoxin	Antitoxin
K6L26_RS07105 (K6L26_07105)	1523648..1524097	+	450	WP_019347713.1	SRPBCC family protein	Toxin
K6L26_RS07110 (K6L26_07110)	1524105..1525322	-	1218	WP_064896896.1	cytochrome P450	-
K6L26_RS07115 (K6L26_07115)	1525315..1525728	-	414	WP_064896894.1	hypothetical protein	-
K6L26_RS07120 (K6L26_07120)	1525725..1526783	-	1059	WP_064896892.1	hypothetical protein	-
K6L26_RS07125 (K6L26_07125)	1526776..1527825	-	1050	WP_064896890.1	dihydrodipicolinate reductase	-
K6L26_RS07130 (K6L26_07130)	1527822..1529042	-	1221	WP_064896888.1	cytochrome P450	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-145)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 150 a.a.
• Molecular weight: 16121.66 Da
• Isoelectric Point: 9.7310

>T212971 WP_019347713.1 NZ_CP081673:1523648-1524097 [Mycolicibacterium farcinogenes]
MAKLSVSVEVPLPPDKAWEHASDLSRYDEWLSIHRAWRSKLPETLEKGTVIDSIVEVKGMLNRVKWTLVNYKPPQSLTLN
GDGRGGVKVKLIGKITPATVDGADGAKVSFDVHLGGPALFGPIGMVVAAALKGDIQQSLNKFKELYASS

Nucleotide

• Length: 450 bp

>T212971 NZ_CP107417:c5062533-5061616 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6529.21 Da
• Isoelectric Point: 4.7045

>AT212971 WP_064896898.1 NZ_CP081673:1523465-1523644 [Mycolicibacterium farcinogenes]
MGFLDKAKDLLSQNADKVEQAIDKAGDLVDEKTQGKYSQHVDKAQEAAKNALNKEEPQQ

Nucleotide

• Length: 180 bp

>AT212971 NZ_CP107417:c5063297-5062539 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1A1W632