Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1944797..1945394 Replicon chromosome
Accession NZ_CP081508
Organism Trueperella pyogenes strain EMSSI21

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K5713_RS08850 Protein ID WP_259243211.1
Coordinates 1944797..1944955 (+) Length 53 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K5713_RS08855 Protein ID WP_259243212.1
Coordinates 1945074..1945394 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5713_RS08825 (K5713_08850) 1939854..1940834 - 981 WP_259243205.1 iron ABC transporter permease -
K5713_RS08830 (K5713_08855) 1940831..1941823 - 993 WP_259243206.1 iron ABC transporter permease -
K5713_RS08835 (K5713_08860) 1941823..1942737 - 915 WP_259243208.1 ABC transporter substrate-binding protein -
K5713_RS08840 (K5713_08865) 1942934..1943290 - 357 WP_259243209.1 iron ABC transporter -
K5713_RS08845 (K5713_08870) 1943618..1944466 - 849 WP_259243210.1 siderophore-interacting protein -
K5713_RS08850 1944797..1944955 + 159 WP_259243211.1 hypothetical protein Toxin
K5713_RS08855 (K5713_08880) 1945074..1945394 + 321 WP_259243212.1 putative addiction module antidote protein Antitoxin
K5713_RS08860 (K5713_08885) 1945492..1945908 + 417 WP_259243213.1 SRPBCC family protein -
K5713_RS08870 (K5713_08895) 1946308..1946934 - 627 WP_126714207.1 alpha/beta fold hydrolase -
K5713_RS08875 (K5713_08900) 1946931..1947950 - 1020 WP_259243214.1 hypothetical protein -
K5713_RS08880 (K5713_08905) 1948010..1949224 - 1215 WP_259243215.1 molybdopterin molybdotransferase MoeA -
K5713_RS08885 (K5713_08910) 1949308..1949955 + 648 WP_259243216.1 5-formyltetrahydrofolate cyclo-ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-52)

Antitoxin

Uncharacterized protein HI1420

(14-102)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5875.90 Da        Isoelectric Point: 10.3606

>T212970 WP_259243211.1 NZ_CP081508:1944797-1944955 [Trueperella pyogenes]
VKIRQTDVYARWFRKLKDVQGTARINIALQRCKIAGEVVGDVKPVGDGVFEM

Download         Length: 159 bp

>T212970 NZ_CP107417:c4905716-4905432 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11379.94 Da        Isoelectric Point: 5.8649

>AT212970 WP_259243212.1 NZ_CP081508:1945074-1945394 [Trueperella pyogenes]
MQQKLLGRDHGRKNSTWDASEYLETKEDIAAYLNAALEEGDPALLQVALGDVAKARGVTAIAREAGVGRESLYKSLSENG
NPSWQTITKVLTALGLKIEVKAIALA

Download         Length: 321 bp

>AT212970 NZ_CP107417:c4905948-4905706 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References