Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1195122..1195605 Replicon chromosome
Accession NZ_CP081502
Organism Streptococcus halichoeri strain Shali_VAS-CPH

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K5J94_RS05755 Protein ID WP_159544238.1
Coordinates 1195345..1195605 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K5J94_RS05750 Protein ID WP_159544240.1
Coordinates 1195122..1195343 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5J94_RS05735 1190318..1192042 + 1725 WP_159549329.1 septation ring formation regulator EzrA -
K5J94_RS05740 1192377..1192838 - 462 WP_159564069.1 YueI family protein -
K5J94_RS05745 1193061..1194368 + 1308 WP_221912606.1 phosphopyruvate hydratase -
K5J94_RS05750 1195122..1195343 + 222 WP_159544240.1 DUF6290 family protein Antitoxin
K5J94_RS05755 1195345..1195605 + 261 WP_159544238.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5J94_RS05760 1196251..1196409 + 159 WP_221912607.1 hypothetical protein -
K5J94_RS05765 1196583..1197656 + 1074 WP_221912608.1 hypothetical protein -
K5J94_RS09540 1197996..1198607 - 612 WP_231700343.1 hypothetical protein -
K5J94_RS09545 1198609..1199082 - 474 WP_231700344.1 DNA/RNA non-specific endonuclease -
K5J94_RS05775 1199392..1200066 - 675 WP_159564065.1 PAS domain-containing protein -
K5J94_RS05780 1200232..1200600 + 369 WP_221913783.1 Rid family detoxifying hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10231.76 Da        Isoelectric Point: 9.9177

>T212937 WP_159544238.1 NZ_CP081502:1195345-1195605 [Streptococcus halichoeri]
MYHIEYSKKAQKQIKKLDKQIQRLLFSWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGNYRLICDIQDNKMIILALEFG
HRGDIY

Download         Length: 261 bp

>T212937 NZ_CP107408:4231717-4231935 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8541.59 Da        Isoelectric Point: 4.7672

>AT212937 WP_159544240.1 NZ_CP081502:1195122-1195343 [Streptococcus halichoeri]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDKYDLKVYNQAYAEYKADPQTISHADFKKELDL

Download         Length: 222 bp

>AT212937 NZ_CP107408:4231316-4231690 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References