Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 988669..989324 Replicon chromosome
Accession NZ_CP081502
Organism Streptococcus halichoeri strain Shali_VAS-CPH

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K5J94_RS04770 Protein ID WP_159560991.1
Coordinates 989163..989324 (-) Length 54 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K5J94_RS04765 Protein ID WP_159564956.1
Coordinates 988669..989121 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5J94_RS04745 984356..986023 + 1668 WP_221913690.1 phosphatidylglycerol lysyltransferase domain-containing protein -
K5J94_RS04750 986720..987451 + 732 WP_159547841.1 acid phosphatase AphA -
K5J94_RS04755 987739..988044 - 306 WP_221913692.1 bacteriocin immunity protein -
K5J94_RS04760 988041..988295 - 255 WP_159795301.1 hypothetical protein -
K5J94_RS04765 988669..989121 - 453 WP_159564956.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K5J94_RS04770 989163..989324 - 162 WP_159560991.1 type II toxin-antitoxin system HicA family toxin Toxin
K5J94_RS09525 989416..989544 - 129 Protein_891 ArpU family transcriptional regulator -
K5J94_RS04780 990074..990286 + 213 WP_221913694.1 hypothetical protein -
K5J94_RS04785 990497..991324 + 828 WP_221913696.1 EbhA -
K5J94_RS04790 991643..992004 + 362 Protein_894 TIGR02328 family protein -
K5J94_RS04795 992124..992306 + 183 WP_159565109.1 putative DNA binding domain-containing protein -
K5J94_RS04800 992507..992743 + 237 WP_159550488.1 DUF2829 domain-containing protein -
K5J94_RS04805 992736..993434 + 699 WP_221913699.1 3-oxoacyl-ACP reductase -
K5J94_RS04810 993500..993949 + 450 WP_221913777.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(1-52)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-73)


Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 5858.80 Da        Isoelectric Point: 10.4115

>T212936 WP_159560991.1 NZ_CP081502:c989324-989163 [Streptococcus halichoeri]
MVKLLTANGWTKTKEGNGSHVKLEKAGEWPITIPHGDINKYTERGIKKQAGLL

Download         Length: 162 bp

>T212936 NZ_CP107408:c2786601-2785279 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16693.69 Da        Isoelectric Point: 4.0109

>AT212936 WP_159564956.1 NZ_CP081502:c989121-988669 [Streptococcus halichoeri]
MLVTYPALFYYDDTDGANAPYFVTFPDFEHSATQGEDMVDAMAMASDWLGINLADYIENGRNIPKPSDINSLSLIDNNPF
GEDADFQLTYDPNKSFVSLVMVDVAKYLGSQEPIKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 453 bp

>AT212936 NZ_CP107408:c2786867-2786601 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References