Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 4182035..4182624 Replicon chromosome
Accession NZ_CP081490
Organism Pseudomonas protegens strain PS1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K5F93_RS18875 Protein ID WP_221808512.1
Coordinates 4182035..4182286 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K5F93_RS18880 Protein ID WP_221808513.1
Coordinates 4182283..4182624 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5F93_RS18850 (K5F93_18850) 4177473..4178219 - 747 WP_221808509.1 amino acid ABC transporter ATP-binding protein -
K5F93_RS18855 (K5F93_18855) 4178216..4178872 - 657 WP_011060581.1 amino acid ABC transporter permease -
K5F93_RS18860 (K5F93_18860) 4178933..4179697 - 765 WP_221808510.1 ABC transporter substrate-binding protein -
K5F93_RS18865 (K5F93_18865) 4179868..4180644 + 777 WP_060838611.1 IclR family transcriptional regulator -
K5F93_RS18870 (K5F93_18870) 4180891..4181946 + 1056 WP_221808511.1 permease -
K5F93_RS18875 (K5F93_18875) 4182035..4182286 + 252 WP_221808512.1 type II toxin-antitoxin system HicA family toxin Toxin
K5F93_RS18880 (K5F93_18880) 4182283..4182624 + 342 WP_221808513.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K5F93_RS18885 (K5F93_18885) 4182914..4183255 + 342 WP_221808514.1 DUF3077 domain-containing protein -
K5F93_RS18890 (K5F93_18890) 4183309..4184409 - 1101 WP_221808515.1 tRNA 2-selenouridine(34) synthase MnmH -
K5F93_RS18895 (K5F93_18895) 4184409..4185443 - 1035 WP_047303467.1 selenide, water dikinase SelD -
K5F93_RS18900 (K5F93_18900) 4185487..4185852 - 366 WP_221808516.1 nuclear transport factor 2 family protein -
K5F93_RS18905 (K5F93_18905) 4186069..4187040 + 972 WP_221808517.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9253.73 Da        Isoelectric Point: 10.4707

>T212930 WP_221808512.1 NZ_CP081490:4182035-4182286 [Pseudomonas protegens]
VSKNDKLLAKLLNDRGTFSWQELLTLLKRLGYTPLEGSGSRVKFDNGDPGAMINLHKPHPGNELKAYIRRQVIEQLKSGG
LIP

Download         Length: 252 bp

>T212930 NZ_CP107406:c6346-6032 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12541.94 Da        Isoelectric Point: 4.8281

>AT212930 WP_221808513.1 NZ_CP081490:4182283-4182624 [Pseudomonas protegens]
VNNLLQYKGYFGSIEVSTEDNCLFGKLQFIRALVSYEGQTVAELEAAFKEAVDDYLDTCEQSGTAPEIPCKGSFNVRVGH
DLHLAAAVAANRQNVSLNDLTRQALNEYLQHHH

Download         Length: 342 bp

>AT212930 NZ_CP107406:c6612-6334 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References