Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA(toxin) |
| Location | 4182035..4182624 | Replicon | chromosome |
| Accession | NZ_CP081490 | ||
| Organism | Pseudomonas protegens strain PS1 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | K5F93_RS18875 | Protein ID | WP_221808512.1 |
| Coordinates | 4182035..4182286 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | K5F93_RS18880 | Protein ID | WP_221808513.1 |
| Coordinates | 4182283..4182624 (+) | Length | 114 a.a. |
Genomic Context
Location: 4179868..4180644 (777 bp)
Type: Others
Protein ID: WP_060838611.1
Type: Others
Protein ID: WP_060838611.1
Location: 4180891..4181946 (1056 bp)
Type: Others
Protein ID: WP_221808511.1
Type: Others
Protein ID: WP_221808511.1
Location: 4182035..4182286 (252 bp)
Type: Toxin
Protein ID: WP_221808512.1
Type: Toxin
Protein ID: WP_221808512.1
Location: 4182283..4182624 (342 bp)
Type: Antitoxin
Protein ID: WP_221808513.1
Type: Antitoxin
Protein ID: WP_221808513.1
Location: 4182914..4183255 (342 bp)
Type: Others
Protein ID: WP_221808514.1
Type: Others
Protein ID: WP_221808514.1
Location: 4186069..4187040 (972 bp)
Type: Others
Protein ID: WP_221808517.1
Type: Others
Protein ID: WP_221808517.1
Location: 4177473..4178219 (747 bp)
Type: Others
Protein ID: WP_221808509.1
Type: Others
Protein ID: WP_221808509.1
Location: 4178216..4178872 (657 bp)
Type: Others
Protein ID: WP_011060581.1
Type: Others
Protein ID: WP_011060581.1
Location: 4178933..4179697 (765 bp)
Type: Others
Protein ID: WP_221808510.1
Type: Others
Protein ID: WP_221808510.1
Location: 4183309..4184409 (1101 bp)
Type: Others
Protein ID: WP_221808515.1
Type: Others
Protein ID: WP_221808515.1
Location: 4184409..4185443 (1035 bp)
Type: Others
Protein ID: WP_047303467.1
Type: Others
Protein ID: WP_047303467.1
Location: 4185487..4185852 (366 bp)
Type: Others
Protein ID: WP_221808516.1
Type: Others
Protein ID: WP_221808516.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5F93_RS18850 (K5F93_18850) | 4177473..4178219 | - | 747 | WP_221808509.1 | amino acid ABC transporter ATP-binding protein | - |
| K5F93_RS18855 (K5F93_18855) | 4178216..4178872 | - | 657 | WP_011060581.1 | amino acid ABC transporter permease | - |
| K5F93_RS18860 (K5F93_18860) | 4178933..4179697 | - | 765 | WP_221808510.1 | ABC transporter substrate-binding protein | - |
| K5F93_RS18865 (K5F93_18865) | 4179868..4180644 | + | 777 | WP_060838611.1 | IclR family transcriptional regulator | - |
| K5F93_RS18870 (K5F93_18870) | 4180891..4181946 | + | 1056 | WP_221808511.1 | permease | - |
| K5F93_RS18875 (K5F93_18875) | 4182035..4182286 | + | 252 | WP_221808512.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K5F93_RS18880 (K5F93_18880) | 4182283..4182624 | + | 342 | WP_221808513.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K5F93_RS18885 (K5F93_18885) | 4182914..4183255 | + | 342 | WP_221808514.1 | DUF3077 domain-containing protein | - |
| K5F93_RS18890 (K5F93_18890) | 4183309..4184409 | - | 1101 | WP_221808515.1 | tRNA 2-selenouridine(34) synthase MnmH | - |
| K5F93_RS18895 (K5F93_18895) | 4184409..4185443 | - | 1035 | WP_047303467.1 | selenide, water dikinase SelD | - |
| K5F93_RS18900 (K5F93_18900) | 4185487..4185852 | - | 366 | WP_221808516.1 | nuclear transport factor 2 family protein | - |
| K5F93_RS18905 (K5F93_18905) | 4186069..4187040 | + | 972 | WP_221808517.1 | LysR substrate-binding domain-containing protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9253.73 Da Isoelectric Point: 10.4707
>T212930 WP_221808512.1 NZ_CP081490:4182035-4182286 [Pseudomonas protegens]
VSKNDKLLAKLLNDRGTFSWQELLTLLKRLGYTPLEGSGSRVKFDNGDPGAMINLHKPHPGNELKAYIRRQVIEQLKSGG
LIP
VSKNDKLLAKLLNDRGTFSWQELLTLLKRLGYTPLEGSGSRVKFDNGDPGAMINLHKPHPGNELKAYIRRQVIEQLKSGG
LIP
Download Length: 252 bp
>T212930 NZ_CP107406:c6346-6032 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12541.94 Da Isoelectric Point: 4.8281
>AT212930 WP_221808513.1 NZ_CP081490:4182283-4182624 [Pseudomonas protegens]
VNNLLQYKGYFGSIEVSTEDNCLFGKLQFIRALVSYEGQTVAELEAAFKEAVDDYLDTCEQSGTAPEIPCKGSFNVRVGH
DLHLAAAVAANRQNVSLNDLTRQALNEYLQHHH
VNNLLQYKGYFGSIEVSTEDNCLFGKLQFIRALVSYEGQTVAELEAAFKEAVDDYLDTCEQSGTAPEIPCKGSFNVRVGH
DLHLAAAVAANRQNVSLNDLTRQALNEYLQHHH
Download Length: 342 bp
>AT212930 NZ_CP107406:c6612-6334 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA