Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1286645..1287276 Replicon chromosome
Accession NZ_CP081490
Organism Pseudomonas protegens strain PS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K5F93_RS06115 Protein ID WP_221810962.1
Coordinates 1286878..1287276 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K5F93_RS06110 Protein ID WP_102860368.1
Coordinates 1286645..1286878 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5F93_RS06085 (K5F93_06085) 1282315..1283442 + 1128 WP_110652277.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
K5F93_RS06090 (K5F93_06090) 1283482..1283841 + 360 WP_221810959.1 amidohydrolase family protein -
K5F93_RS06095 (K5F93_06095) 1283976..1284416 + 441 WP_221810960.1 DUF3592 domain-containing protein -
K5F93_RS06100 (K5F93_06100) 1284421..1285005 + 585 WP_060840910.1 hypothetical protein -
K5F93_RS06105 (K5F93_06105) 1285030..1286277 - 1248 WP_221810961.1 aspartate aminotransferase family protein -
K5F93_RS06110 (K5F93_06110) 1286645..1286878 + 234 WP_102860368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K5F93_RS06115 (K5F93_06115) 1286878..1287276 + 399 WP_221810962.1 tRNA(fMet)-specific endonuclease VapC Toxin
K5F93_RS06120 (K5F93_06120) 1287299..1287412 - 114 WP_260627405.1 DUF2938 domain-containing protein -
K5F93_RS06125 (K5F93_06125) 1287753..1289801 + 2049 WP_221810963.1 c-type cytochrome -
K5F93_RS06130 (K5F93_06130) 1289938..1290507 + 570 WP_221810964.1 hypothetical protein -
K5F93_RS06135 (K5F93_06135) 1290517..1290879 - 363 WP_221810965.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15063.42 Da        Isoelectric Point: 7.9035

>T212928 WP_221810962.1 NZ_CP081490:1286878-1287276 [Pseudomonas protegens]
MLKYMLDTNICIFTIKNKPEQVREAFRRHQGRLCISTITLMELIYGAEKSAIPEKNLSRVESFVARLQVLDYDDAAAIHS
GQLHAELVRQGKQIGPYDQLIAGHARSLGLTLITNNLREFERVPGLRVEDWV

Download         Length: 399 bp

>T212928 NZ_CP107404:c78392-78243 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8787.73 Da        Isoelectric Point: 4.2342

>AT212928 WP_102860368.1 NZ_CP081490:1286645-1286878 [Pseudomonas protegens]
METGSVFKSNRSQAIRMPKAVALPDDVTRVDIVAIGRTRIITPAGESWDSWFDEDDRVSADFMNERDQPAEQVREEF

Download         Length: 234 bp

>AT212928 NZ_CP107404:78437-78496 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References