Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/-
Location 124700..125305 Replicon chromosome
Accession NZ_CP081490
Organism Pseudomonas protegens strain PS1

Toxin (Protein)


Gene name PfiT Uniprot ID -
Locus tag K5F93_RS00595 Protein ID WP_060844990.1
Coordinates 124961..125305 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A7Y1CEW2
Locus tag K5F93_RS00590 Protein ID WP_025131512.1
Coordinates 124700..124948 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5F93_RS00565 (K5F93_00565) 120013..121020 - 1008 WP_221810226.1 NAD(P)-dependent oxidoreductase -
K5F93_RS00570 (K5F93_00570) 121020..122033 - 1014 WP_221810227.1 beta-ketoacyl-ACP synthase 3 -
K5F93_RS00575 (K5F93_00575) 122081..122728 - 648 WP_221810228.1 YcxB family protein -
K5F93_RS00580 (K5F93_00580) 122826..123605 - 780 WP_260627384.1 hypothetical protein -
K5F93_RS00585 (K5F93_00585) 123737..124090 - 354 WP_221810229.1 DUF3077 domain-containing protein -
K5F93_RS00590 (K5F93_00590) 124700..124948 + 249 WP_025131512.1 prevent-host-death protein Antitoxin
K5F93_RS00595 (K5F93_00595) 124961..125305 + 345 WP_060844990.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5F93_RS00600 (K5F93_00600) 125457..126881 - 1425 WP_159894151.1 aspartate ammonia-lyase -
K5F93_RS00605 (K5F93_00605) 127063..127980 + 918 WP_102862325.1 LysR substrate-binding domain-containing protein -
K5F93_RS00610 (K5F93_00610) 128439..128930 + 492 WP_016967060.1 5-(carboxyamino)imidazole ribonucleotide mutase -
K5F93_RS00615 (K5F93_00615) 128942..130024 + 1083 WP_221810230.1 5-(carboxyamino)imidazole ribonucleotide synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12868.57 Da        Isoelectric Point: 4.2876

>T212927 WP_060844990.1 NZ_CP081490:124961-125305 [Pseudomonas protegens]
MPTLTIRYTETAQQSIEDQIVHLADYSDLKSAFERLDAVIDALQDKLLSAPLGYPVSPQASDLGILHYRELNTDGYRVFY
EIVDADQAIVVGLVLRDKQSVEQALIRYCLLHTD

Download         Length: 345 bp

>T212927 NZ_CP107403:4756735-4756837 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9410.89 Da        Isoelectric Point: 9.8184

>AT212927 WP_025131512.1 NZ_CP081490:124700-124948 [Pseudomonas protegens]
MRVETVSFLKRYASDLPLEEPMVVTQNGVPVYVVESYVERKRRDEAVALVKLLAVSSREYAQGKHCSTDELKARLSKRFA
HK

Download         Length: 249 bp

>AT212927 NZ_CP107403:c4756844-4756699 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y1CEW2

References