Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 484795..485432 Replicon chromosome
Accession NZ_CP081488
Organism Bacillus velezensis strain LZN01

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag K4120_RS02460 Protein ID WP_003156187.1
Coordinates 485082..485432 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I2HMS5
Locus tag K4120_RS02455 Protein ID WP_003156188.1
Coordinates 484795..485076 (+) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4120_RS02435 (K4120_02435) 481160..481759 - 600 WP_003156193.1 rhomboid family intramembrane serine protease -
K4120_RS02440 (K4120_02440) 481852..482217 + 366 WP_007410229.1 holo-ACP synthase -
K4120_RS02445 (K4120_02445) 482382..483389 + 1008 WP_007410230.1 outer membrane lipoprotein carrier protein LolA -
K4120_RS02450 (K4120_02450) 483506..484675 + 1170 WP_032866888.1 alanine racemase -
K4120_RS02455 (K4120_02455) 484795..485076 + 282 WP_003156188.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
K4120_RS02460 (K4120_02460) 485082..485432 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
K4120_RS02465 (K4120_02465) 485550..486371 + 822 WP_003156182.1 STAS domain-containing protein -
K4120_RS02470 (K4120_02470) 486376..486741 + 366 WP_003156180.1 RsbT antagonist protein RsbS -
K4120_RS02475 (K4120_02475) 486744..487145 + 402 WP_003156178.1 anti-sigma regulatory factor -
K4120_RS02480 (K4120_02480) 487157..488164 + 1008 WP_007410233.1 PP2C family protein-serine/threonine phosphatase -
K4120_RS02485 (K4120_02485) 488228..488557 + 330 WP_003156176.1 anti-sigma factor antagonist RsbV -
K4120_RS02490 (K4120_02490) 488554..489036 + 483 WP_003156173.1 anti-sigma B factor RsbW -
K4120_RS02495 (K4120_02495) 489002..489790 + 789 WP_003156171.1 RNA polymerase sigma factor SigB -
K4120_RS02500 (K4120_02500) 489790..490392 + 603 WP_007410234.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-111)

Antitoxin

(12-45)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T212899 WP_003156187.1 NZ_CP081488:485082-485432 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T212899 NZ_CP107396:c6346-6032 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10562.92 Da        Isoelectric Point: 6.4706

>AT212899 WP_003156188.1 NZ_CP081488:484795-485076 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT212899 NZ_CP107396:c6612-6334 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8


Antitoxin

Source ID Structure
AlphaFold DB I2HMS5

References