212897

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1629293..1630937 Replicon chromosome
Accession NZ_CP081486
Organism Pasteurella multocida strain Pm3

Toxin (Protein)


Gene name hipA Uniprot ID V4NI19
Locus tag K5E88_RS07670 Protein ID WP_005752891.1
Coordinates 1629630..1630937 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V4NAB0
Locus tag K5E88_RS07665 Protein ID WP_005752888.1
Coordinates 1629293..1629628 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5E88_RS07640 (K5E88_07640) 1625371..1626030 + 660 WP_005724855.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
K5E88_RS07645 (K5E88_07645) 1626094..1626663 + 570 WP_014326417.1 Der GTPase-activating protein YihI -
K5E88_RS07650 (K5E88_07650) 1626669..1627097 + 429 WP_005719208.1 DUF2489 domain-containing protein -
K5E88_RS07655 (K5E88_07655) 1627121..1628488 + 1368 WP_016504414.1 oxygen-independent coproporphyrinogen III oxidase -
K5E88_RS07660 (K5E88_07660) 1628529..1629197 + 669 WP_014326419.1 nitroreductase family protein -
K5E88_RS07665 (K5E88_07665) 1629293..1629628 - 336 WP_005752888.1 helix-turn-helix transcriptional regulator Antitoxin
K5E88_RS07670 (K5E88_07670) 1629630..1630937 - 1308 WP_005752891.1 HipA domain-containing protein Toxin
K5E88_RS07675 (K5E88_07675) 1631156..1632292 + 1137 WP_075266242.1 anhydro-N-acetylmuramic acid kinase -
K5E88_RS07680 (K5E88_07680) 1632358..1634940 - 2583 WP_014326421.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-375)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50526.31 Da        Isoelectric Point: 4.9118

>T212897 WP_005752891.1 NZ_CP081486:c1630937-1629630 [Pasteurella multocida]
MEKLTLQIYLEQAWCDLAFLYFDSETYQLCNFEYLTDYVVQHYGKTGEHAVSLNYPVNVFIDDTTSLWSWLSDIAPAGAS
RRYWLEALDIKQESEEKQQFLLLKHAAISPIGNLRIKDAVPEQVEVRLFDLDKAKDRQSDFLEYVNQSGAMVGGATGAGG
EAPKLLLKRRENQVWIDNQQQGQDQDVSYLVKYPRGNYSPIDCDILRAEYHYYQELAQLGFDTIDTTRMRLEEGKRYPSL
WLPRFDIVQREGKTHRLAFESVYSLLQKQGGVLDHETTLRQLIERISTARLQFAQTDFVIEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQRIWLAPIYDFAPMRADPEGIIRTTTWQTKGEYPQEFAGEYHFERIAEVLADLVEPTLLMQELRRLAGSLVD
LKSRLVQRNLPQSILDFPAIGFDYLPEKLKKWGLI

Download         Length: 1308 bp

>T212897 NZ_CP107395:c78337-78188 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12520.60 Da        Isoelectric Point: 10.5259

>AT212897 WP_005752888.1 NZ_CP081486:c1629628-1629293 [Pasteurella multocida]
MQITRRNASTKGASVAEIDRKKVRNEIIQAMLMGELSQGEALRKLRIEMFGINQQHYIQLVKVSRQTLSNIENDKGNYSV
ETINKVFKPFGLELGLVPVSKALLKELFSTA

Download         Length: 336 bp

>AT212897 NZ_CP107395:78382-78441 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V4NI19

Antitoxin

Source ID Structure
AlphaFold DB V4NAB0

References