Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 47085..47686 Replicon chromosome
Accession NZ_CP081486
Organism Pasteurella multocida strain Pm3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K5E88_RS00310 Protein ID WP_071523842.1
Coordinates 47085..47399 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K5E88_RS00315 Protein ID WP_102822911.1
Coordinates 47396..47686 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5E88_RS00265 (K5E88_00265) 42109..43008 - 900 WP_221812491.1 hypothetical protein -
K5E88_RS00270 (K5E88_00270) 43011..43172 - 162 WP_199764787.1 hypothetical protein -
K5E88_RS00275 (K5E88_00275) 43185..43421 - 237 WP_078801815.1 hypothetical protein -
K5E88_RS00280 (K5E88_00280) 43393..43692 - 300 WP_014391453.1 hypothetical protein -
K5E88_RS00285 (K5E88_00285) 43840..44070 + 231 WP_223251317.1 hypothetical protein -
K5E88_RS00290 (K5E88_00290) 44132..44818 - 687 WP_221812492.1 Bro-N domain-containing protein -
K5E88_RS00295 (K5E88_00295) 45171..45698 + 528 WP_075272491.1 hypothetical protein -
K5E88_RS00300 (K5E88_00300) 45789..46052 - 264 WP_071522857.1 hypothetical protein -
K5E88_RS00305 (K5E88_00305) 46277..46507 - 231 WP_016533507.1 hypothetical protein -
K5E88_RS00310 (K5E88_00310) 47085..47399 + 315 WP_071523842.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5E88_RS00315 (K5E88_00315) 47396..47686 + 291 WP_102822911.1 putative addiction module antidote protein Antitoxin
K5E88_RS00320 (K5E88_00320) 47712..48149 - 438 WP_078819883.1 hypothetical protein -
K5E88_RS00325 (K5E88_00325) 48523..49200 - 678 WP_016569989.1 XRE family transcriptional regulator -
K5E88_RS00330 (K5E88_00330) 49324..49521 + 198 WP_014390719.1 helix-turn-helix domain-containing protein -
K5E88_RS00335 (K5E88_00335) 49570..50022 + 453 WP_102822910.1 hypothetical protein -
K5E88_RS11455 50090..50224 + 135 WP_016569987.1 hypothetical protein -
K5E88_RS00340 (K5E88_00340) 50276..50536 + 261 WP_016569986.1 Rha family transcriptional regulator -
K5E88_RS00345 (K5E88_00345) 50533..50886 + 354 WP_014390722.1 HNH endonuclease signature motif containing protein -
K5E88_RS00350 (K5E88_00350) 50888..51790 + 903 WP_016533442.1 hypothetical protein -
K5E88_RS00355 (K5E88_00355) 51790..52479 + 690 WP_064964930.1 replication protein P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 35037..56363 21326


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11777.68 Da        Isoelectric Point: 9.5553

>T212896 WP_071523842.1 NZ_CP081486:47085-47399 [Pasteurella multocida]
MLDIIETTVFNKWLKELKDLSAKAAILARISRAKSGNFGDHKSVGDGLYEMRIMKGAGYRIYYAQYKDVTYLLICGGDKS
TQKADIAKAKALWEEIKQKEEINV

Download         Length: 315 bp

>T212896 NZ_CP107394:5430998-5432320 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10560.20 Da        Isoelectric Point: 5.7134

>AT212896 WP_102822911.1 NZ_CP081486:47396-47686 [Pasteurella multocida]
MSKKVELKPFDIAEYLDSEEMIAAYLSEVLETGDTNEFISALGDVARARGMTELAAKTGLGRESLYKTLSHGSKPRFDTI
MKITQALGIKLVPTHI

Download         Length: 291 bp

>AT212896 NZ_CP107394:5430732-5430998 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References