Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1082125..1082666 Replicon chromosome
Accession NZ_CP081457
Organism Pseudomonas syringae pv. actinidifoliorum ICMP 18803

Toxin (Protein)


Gene name relE Uniprot ID S6UY68
Locus tag A237_RS04975 Protein ID WP_017700185.1
Coordinates 1082125..1082400 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K8LU58
Locus tag A237_RS04980 Protein ID WP_003382249.1
Coordinates 1082400..1082666 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A237_RS04955 (A237_004945) 1077256..1078281 - 1026 WP_017700182.1 TRAP transporter substrate-binding protein -
A237_RS04960 (A237_004950) 1078338..1079222 - 885 WP_017700183.1 SMP-30/gluconolactonase/LRE family protein -
A237_RS04965 (A237_004955) 1079279..1080106 - 828 WP_017700184.1 NAD(P)-dependent oxidoreductase -
A237_RS04970 (A237_004960) 1080285..1081553 - 1269 WP_017698468.1 OprD family porin -
A237_RS04975 (A237_004965) 1082125..1082400 - 276 WP_017700185.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A237_RS04980 (A237_004970) 1082400..1082666 - 267 WP_003382249.1 ribbon-helix-helix domain-containing protein Antitoxin
A237_RS04985 (A237_004975) 1082829..1084751 - 1923 WP_017700186.1 methyl-accepting chemotaxis protein -
A237_RS04990 (A237_004980) 1085110..1086990 + 1881 WP_003382247.1 methyl-accepting chemotaxis protein -
A237_RS04995 (A237_004985) 1087118..1087381 - 264 WP_017700187.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-45)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10738.41 Da        Isoelectric Point: 7.0123

>T212876 WP_017700185.1 NZ_CP081457:c1082400-1082125 [Pseudomonas syringae pv. actinidifoliorum ICMP 18803]
MELMWTSKALSDVARLYDFLAVANQPAAAQTVQKLTAAPIMLLSNPRIGERLEEFEPRDVRRIQIGRYEMRYEIVDSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T212876 NZ_CP107390:c2373114-2372767 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9934.24 Da        Isoelectric Point: 5.7066

>AT212876 WP_003382249.1 NZ_CP081457:c1082666-1082400 [Pseudomonas syringae pv. actinidifoliorum ICMP 18803]
MTTKTRSVTAHIPEQLAEKVDLMAERLERSKNWIVKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWADSLST
ATPLPVPR

Download         Length: 267 bp

>AT212876 NZ_CP107390:c2372767-2372468 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M4KLP6

Antitoxin

Source ID Structure
AlphaFold DB A0A0K8LU58

References