Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2211541..2212055 Replicon chromosome
Accession NZ_CP081354
Organism Staphylococcus aureus strain SQL1

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag K1X69_RS11055 Protein ID WP_000581792.1
Coordinates 2211541..2211750 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag K1X69_RS11060 Protein ID WP_000138932.1
Coordinates 2211762..2212055 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1X69_RS11035 (2207049) 2207049..2208407 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
K1X69_RS11040 (2208422) 2208422..2209492 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
K1X69_RS11045 (2209810) 2209810..2211012 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
K1X69_RS11050 (2211276) 2211276..2211413 - 138 WP_000828354.1 Lmo0850 family protein -
K1X69_RS11055 (2211541) 2211541..2211750 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
K1X69_RS11060 (2211762) 2211762..2212055 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
K1X69_RS11065 (2212221) 2212221..2213705 + 1485 WP_000571549.1 cardiolipin synthase -
K1X69_RS11070 (2213733) 2213733..2214380 + 648 WP_001187629.1 HD domain-containing protein -
K1X69_RS11075 (2215193) 2215193..2216065 - 873 WP_000725802.1 membrane protein insertase YidC -
K1X69_RS11080 (2216151) 2216151..2216792 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T212870 WP_000581792.1 NZ_CP081354:c2211750-2211541 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T212870 NZ_CP107385:c68218-68069 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT212870 WP_000138932.1 NZ_CP081354:c2212055-2211762 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT212870 NZ_CP107385:68263-68322 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References