Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5268352..5269087 Replicon chromosome
Accession NZ_CP081351
Organism Klebsiella michiganensis strain CCRI-24235

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag Km24235_RS24700 Protein ID WP_222582062.1
Coordinates 5268352..5268705 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag Km24235_RS24705 Protein ID WP_222582475.1
Coordinates 5268761..5269087 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Km24235_RS24670 (Km24235_4897) 5263357..5264151 + 795 WP_225935962.1 DNA/RNA non-specific endonuclease -
Km24235_RS24675 (Km24235_4898) 5264441..5264764 + 324 WP_064345376.1 endoribonuclease SymE -
Km24235_RS24680 (Km24235_4899) 5264923..5265357 + 435 WP_004098173.1 VOC family protein -
Km24235_RS24685 (Km24235_4900) 5265523..5266215 + 693 WP_225935963.1 hypothetical protein -
Km24235_RS24690 (Km24235_4901) 5266443..5267240 - 798 WP_222582061.1 helix-turn-helix transcriptional regulator -
Km24235_RS24695 (Km24235_4902) 5267384..5268230 - 847 Protein_4868 DUF4942 domain-containing protein -
Km24235_RS24700 (Km24235_4904) 5268352..5268705 - 354 WP_222582062.1 TA system toxin CbtA family protein Toxin
Km24235_RS24705 (Km24235_4905) 5268761..5269087 - 327 WP_222582475.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
Km24235_RS24710 (Km24235_4906) 5269145..5269366 - 222 WP_047724679.1 DUF987 domain-containing protein -
Km24235_RS24715 (Km24235_4907) 5269380..5269859 - 480 WP_222582063.1 DNA repair protein RadC -
Km24235_RS24720 (Km24235_4908) 5269871..5270314 - 444 WP_222582064.1 antirestriction protein -
Km24235_RS24725 (Km24235_4909) 5270394..5270642 - 249 WP_222582065.1 DUF905 domain-containing protein -
Km24235_RS24730 (Km24235_4910) 5270648..5271472 - 825 WP_222582066.1 DUF932 domain-containing protein -
Km24235_RS24735 (Km24235_4911) 5272013..5272645 + 633 WP_072024984.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5264923..5320655 55732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13104.00 Da        Isoelectric Point: 6.7004

>T212860 WP_222582062.1 NZ_CP081351:c5268705-5268352 [Klebsiella michiganensis]
MQTQSSPLVRAASSRPSPVGVWQTLLTCLLEHHYGLTLNDTPFSDEQVIQQHIDAGISLCDALNFIVEKYELLRTDRPGF
SIREQSPFITPIDILRARKATGLMNCGTYKEVTAITR

Download         Length: 354 bp

>T212860 NZ_CP107383:c2737721-2736399 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12134.84 Da        Isoelectric Point: 6.6242

>AT212860 WP_222582475.1 NZ_CP081351:c5269087-5268761 [Klebsiella michiganensis]
ISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQAFPVLMKQLELMLTSGELNPRHQHCVTLYA
KGLTCEADTLGSHGYVYIAIYPTPVATA

Download         Length: 327 bp

>AT212860 NZ_CP107383:c2737987-2737721 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References