Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4766908..4767727 Replicon chromosome
Accession NZ_CP081351
Organism Klebsiella michiganensis strain CCRI-24235

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag Km24235_RS22420 Protein ID WP_004110819.1
Coordinates 4767470..4767727 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag Km24235_RS22415 Protein ID WP_047684097.1
Coordinates 4766908..4767459 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Km24235_RS22400 (Km24235_4444) 4763132..4764040 - 909 WP_032693197.1 transcriptional regulator GcvA -
Km24235_RS22405 (Km24235_4445) 4764160..4765047 + 888 WP_032718961.1 DMT family transporter -
Km24235_RS29040 4765262..4766008 - 747 WP_223226754.1 class I SAM-dependent methyltransferase -
Km24235_RS29045 4766384..4766794 - 411 Protein_4426 class I SAM-dependent methyltransferase -
Km24235_RS22415 (Km24235_4447) 4766908..4767459 - 552 WP_047684097.1 N-acetyltransferase Antitoxin
Km24235_RS22420 (Km24235_4448) 4767470..4767727 - 258 WP_004110819.1 YjhX family toxin Toxin
Km24235_RS22425 (Km24235_4449) 4768403..4769587 + 1185 WP_014228054.1 mannonate dehydratase -
Km24235_RS22430 (Km24235_4450) 4769661..4771136 + 1476 WP_014228053.1 fructuronate reductase -
Km24235_RS22435 (Km24235_4451) 4771275..4772051 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(22-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T212859 WP_004110819.1 NZ_CP081351:c4767727-4767470 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T212859 NZ_CP107383:2009758-2009860 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 19842.60 Da        Isoelectric Point: 6.4897

>AT212859 WP_047684097.1 NZ_CP081351:c4767459-4766908 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAACYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp

>AT212859 NZ_CP107383:c2009867-2009722 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References