212844

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 21166..21716 Replicon plasmid pSE5419-1
Accession NZ_CP081347
Organism Pseudomonas aeruginosa strain SE5419

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K5B69_RS31935 Protein ID WP_019727125.1
Coordinates 21441..21716 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6B1YL09
Locus tag K5B69_RS31930 Protein ID WP_019727126.1
Coordinates 21166..21441 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5B69_RS31890 (K5B69_31890) 17587..17964 - 378 WP_019727137.1 hypothetical protein -
K5B69_RS31895 (K5B69_31895) 18007..18291 - 285 WP_019727136.1 hypothetical protein -
K5B69_RS31900 (K5B69_31900) 18350..18601 + 252 WP_019727135.1 hypothetical protein -
K5B69_RS31905 (K5B69_31905) 18651..18899 - 249 WP_034073355.1 hypothetical protein -
K5B69_RS31910 (K5B69_31910) 19193..19525 - 333 WP_034055802.1 hypothetical protein -
K5B69_RS31915 (K5B69_31915) 19518..19826 - 309 WP_034055800.1 TrfB-related DNA-binding protein -
K5B69_RS31920 (K5B69_31920) 20150..20443 - 294 WP_019727128.1 hypothetical protein -
K5B69_RS31925 (K5B69_31925) 20504..20890 - 387 WP_034019111.1 hypothetical protein -
K5B69_RS31930 (K5B69_31930) 21166..21441 + 276 WP_019727126.1 ribbon-helix-helix domain-containing protein Antitoxin
K5B69_RS31935 (K5B69_31935) 21441..21716 + 276 WP_019727125.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5B69_RS31940 (K5B69_31940) 21807..22217 - 411 WP_221612273.1 hypothetical protein -
K5B69_RS31945 (K5B69_31945) 22585..22905 - 321 WP_019727123.1 hypothetical protein -
K5B69_RS31950 (K5B69_31950) 23108..23296 - 189 WP_058133872.1 hypothetical protein -
K5B69_RS31955 (K5B69_31955) 23386..23580 - 195 WP_019727121.1 hypothetical protein -
K5B69_RS31960 (K5B69_31960) 23663..23854 - 192 WP_003142924.1 hypothetical protein -
K5B69_RS31965 (K5B69_31965) 23954..25015 - 1062 WP_221612274.1 DNA-binding protein -
K5B69_RS31970 (K5B69_31970) 25299..26093 - 795 WP_031655076.1 DUF3560 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..53860 53860


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-48)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10779.36 Da        Isoelectric Point: 7.1659

>T212844 WP_019727125.1 NZ_CP081347:21441-21716 [Pseudomonas aeruginosa]
MELKWTSKGLSDVARLYEFLATVNREAAARTVQQLTSAPTALLTNPRLGERLEEFEPRDVRRILIGHYEMRYEILDSCIY
VLRLWHTREDR

Download         Length: 276 bp

>T212844 NZ_CP107379:2016773-2016875 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10142.32 Da        Isoelectric Point: 4.8433

>AT212844 WP_019727126.1 NZ_CP081347:21166-21441 [Pseudomonas aeruginosa]
MSTAAKPTRTVTAHVPVDLAERVDAIAERLERSKNWIVRQALSAWIDQEDERSRLTREALDDVDAGRVVDHQAVQAWAES
LGTDSPLPVPR

Download         Length: 276 bp

>AT212844 NZ_CP107379:c2016882-2016737 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1YL09

References