Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4692870..4694128 Replicon chromosome
Accession NZ_CP081346
Organism Pseudomonas aeruginosa strain SE5419

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag K5B69_RS21980 Protein ID WP_028681273.1
Coordinates 4692870..4693625 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag K5B69_RS21985 Protein ID WP_028681272.1
Coordinates 4693760..4694128 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5B69_RS21970 (K5B69_21970) 4688041..4690584 + 2544 WP_028681274.1 acyl-homoserine-lactone acylase QuiP -
K5B69_RS21975 (K5B69_21975) 4690739..4692100 - 1362 WP_003081943.1 DNA recombination protein RmuC -
K5B69_RS21980 (K5B69_21980) 4692870..4693625 - 756 WP_028681273.1 RES family NAD+ phosphorylase Toxin
K5B69_RS21985 (K5B69_21985) 4693760..4694128 - 369 WP_028681272.1 DUF2384 domain-containing protein Antitoxin
K5B69_RS21990 (K5B69_21990) 4694201..4695487 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
K5B69_RS21995 (K5B69_21995) 4695543..4697132 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
K5B69_RS22000 (K5B69_22000) 4697211..4697687 + 477 WP_003112531.1 hypothetical protein -
K5B69_RS22005 (K5B69_22005) 4697690..4697965 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28262.43 Da        Isoelectric Point: 7.7294

>T212841 WP_028681273.1 NZ_CP081346:c4693625-4692870 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

>T212841 NZ_CP107379:329348-329716 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13395.68 Da        Isoelectric Point: 10.2722

>AT212841 WP_028681272.1 NZ_CP081346:c4694128-4693760 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGRVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT212841 NZ_CP107379:329130-329351 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References