Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3923747..3924789 | Replicon | chromosome |
| Accession | NZ_CP081346 | ||
| Organism | Pseudomonas aeruginosa strain SE5419 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | K5B69_RS18355 | Protein ID | WP_003153636.1 |
| Coordinates | 3923747..3924322 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | K5B69_RS18360 | Protein ID | WP_003050245.1 |
| Coordinates | 3924319..3924789 (-) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5B69_RS18330 (K5B69_18330) | 3920185..3920910 | - | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
| K5B69_RS18335 (K5B69_18335) | 3920949..3921851 | - | 903 | WP_053817030.1 | CBASS oligonucleotide cyclase | - |
| K5B69_RS18340 (K5B69_18340) | 3921851..3922351 | - | 501 | WP_003090159.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| K5B69_RS18345 (K5B69_18345) | 3922348..3922818 | - | 471 | WP_053817029.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
| K5B69_RS18350 (K5B69_18350) | 3922815..3923729 | - | 915 | WP_003050256.1 | AAA family ATPase | - |
| K5B69_RS18355 (K5B69_18355) | 3923747..3924322 | - | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| K5B69_RS18360 (K5B69_18360) | 3924319..3924789 | - | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| K5B69_RS18365 (K5B69_18365) | 3924993..3925376 | + | 384 | WP_053817028.1 | RAQPRD family integrative conjugative element protein | - |
| K5B69_RS18370 (K5B69_18370) | 3925373..3925606 | + | 234 | WP_053817027.1 | TIGR03758 family integrating conjugative element protein | - |
| K5B69_RS18375 (K5B69_18375) | 3925623..3925982 | + | 360 | WP_012248080.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| K5B69_RS18380 (K5B69_18380) | 3925994..3926392 | + | 399 | WP_003153632.1 | TIGR03750 family conjugal transfer protein | - |
| K5B69_RS18385 (K5B69_18385) | 3926389..3927081 | + | 693 | WP_004350603.1 | TIGR03746 family integrating conjugative element protein | - |
| K5B69_RS18390 (K5B69_18390) | 3927078..3927989 | + | 912 | WP_004350604.1 | TIGR03749 family integrating conjugative element protein | - |
| K5B69_RS18395 (K5B69_18395) | 3927979..3929397 | + | 1419 | WP_004350605.1 | TIGR03752 family integrating conjugative element protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 3872906..3979188 | 106282 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T212840 WP_003153636.1 NZ_CP081346:c3924322-3923747 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T212840 NZ_CP107378:2292-2558 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT212840 WP_003050245.1 NZ_CP081346:c3924789-3924319 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT212840 NZ_CP107378:2084-2308 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|