Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4083962..4084614 Replicon chromosome
Accession NZ_CP081342
Organism Pantoea ananatis strain TZ39

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag K4732_RS18965 Protein ID WP_033778077.1
Coordinates 4084216..4084614 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag K4732_RS18960 Protein ID WP_028724117.1
Coordinates 4083962..4084192 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4732_RS18945 (K4732_18945) 4079932..4081140 + 1209 WP_221611346.1 conjugal transfer protein TraF -
K4732_RS18950 (K4732_18950) 4081194..4081745 + 552 WP_221611347.1 hypothetical protein -
K4732_RS18955 (K4732_18955) 4082214..4083374 - 1161 WP_221611348.1 IS30 family transposase -
K4732_RS18960 (K4732_18960) 4083962..4084192 + 231 WP_028724117.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K4732_RS18965 (K4732_18965) 4084216..4084614 + 399 WP_033778077.1 type II toxin-antitoxin system VapC family toxin Toxin
K4732_RS18970 (K4732_18970) 4084841..4085716 - 876 WP_221611349.1 N-acetylmuramoyl-L-alanine amidase -
K4732_RS18975 (K4732_18975) 4085746..4086027 - 282 WP_028724120.1 LuxR C-terminal-related transcriptional regulator -
K4732_RS18980 (K4732_18980) 4086436..4086993 + 558 WP_028724121.1 fimbrial protein -
K4732_RS18985 (K4732_18985) 4087056..4087727 + 672 WP_221611350.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4082214..4083278 1064


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14290.62 Da        Isoelectric Point: 7.2161

>T212828 WP_033778077.1 NZ_CP081342:4084216-4084614 [Pantoea ananatis]
MLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYAEMRFGASGPKASPRHVQLVDAFCARLDAVLPWDRAAVDAT
TEIKVSLRLAGTPIGPNDTAIAGHAITVGAILVTNNVREFARVPGLALEDWV

Download         Length: 399 bp

>T212828 NZ_CP107372:c2737721-2736399 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8702.83 Da        Isoelectric Point: 4.6158

>AT212828 WP_028724117.1 NZ_CP081342:4083962-4084192 [Pantoea ananatis]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFLELEKADPHFMAERGDVVSDEGRFDL

Download         Length: 231 bp

>AT212828 NZ_CP107372:c2737987-2737721 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References