Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3375839..3376456 Replicon chromosome
Accession NZ_CP081342
Organism Pantoea ananatis strain TZ39

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag K4732_RS15770 Protein ID WP_028723979.1
Coordinates 3376241..3376456 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag K4732_RS15765 Protein ID WP_028723978.1
Coordinates 3375839..3376216 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4732_RS15735 (K4732_15735) 3372125..3372379 + 255 WP_014606427.1 type B 50S ribosomal protein L31 -
K4732_RS15740 (K4732_15740) 3372391..3372531 + 141 WP_014606428.1 type B 50S ribosomal protein L36 -
K4732_RS15745 (K4732_15745) 3372591..3373469 - 879 WP_047714454.1 metal ABC transporter substrate-binding protein -
K4732_RS15750 (K4732_15750) 3373482..3374321 - 840 WP_047714453.1 metal ABC transporter permease -
K4732_RS15755 (K4732_15755) 3374318..3374986 - 669 WP_028723976.1 ABC transporter ATP-binding protein -
K4732_RS15760 (K4732_15760) 3375339..3375692 + 354 WP_028723977.1 hypothetical protein -
K4732_RS15765 (K4732_15765) 3375839..3376216 + 378 WP_028723978.1 Hha toxicity modulator TomB Antitoxin
K4732_RS15770 (K4732_15770) 3376241..3376456 + 216 WP_028723979.1 HHA domain-containing protein Toxin
K4732_RS15780 (K4732_15780) 3376854..3377165 + 312 WP_028723980.1 MGMT family protein -
K4732_RS15785 (K4732_15785) 3377214..3377771 - 558 WP_013024901.1 YbaY family lipoprotein -
K4732_RS15790 (K4732_15790) 3377964..3378827 + 864 WP_064365625.1 acyl-CoA thioesterase II -
K4732_RS15795 (K4732_15795) 3378874..3380163 - 1290 WP_028723982.1 ammonium transporter AmtB -
K4732_RS15800 (K4732_15800) 3380198..3380536 - 339 WP_013024898.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8542.94 Da        Isoelectric Point: 9.4825

>T212827 WP_028723979.1 NZ_CP081342:3376241-3376456 [Pantoea ananatis]
MNKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDEELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 216 bp

>T212827 NZ_CP107372:2009758-2009860 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14709.35 Da        Isoelectric Point: 4.4069

>AT212827 WP_028723978.1 NZ_CP081342:3375839-3376216 [Pantoea ananatis]
MDEYSPKRHDIAQLKYLCESLFDESMATLTDSHHGWVNDPTAESNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSNYSVNTQDLQRWQRSAKRLFNVFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT212827 NZ_CP107372:c2009867-2009722 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References