Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4461657..4462460 Replicon chromosome
Accession NZ_CP081314
Organism Citrobacter farmeri strain CCRI-24236

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7L6TYH6
Locus tag Cf24236_RS21295 Protein ID WP_047358707.1
Coordinates 4462080..4462460 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7L6TXP6
Locus tag Cf24236_RS21290 Protein ID WP_047358708.1
Coordinates 4461657..4462022 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Cf24236_RS21250 (Cf24236_4234) 4456730..4457617 + 888 WP_047358715.1 50S ribosome-binding GTPase -
Cf24236_RS21255 (Cf24236_4235) 4457823..4458224 + 402 WP_047358714.1 hypothetical protein -
Cf24236_RS21260 (Cf24236_4236) 4458321..4458788 + 468 WP_222563728.1 hypothetical protein -
Cf24236_RS21265 (Cf24236_4237) 4458979..4459230 + 252 WP_047358712.1 DUF905 family protein -
Cf24236_RS21270 (Cf24236_4238) 4459348..4460166 + 819 WP_047358711.1 DUF932 domain-containing protein -
Cf24236_RS21275 (Cf24236_4239) 4460435..4460908 + 474 WP_047358733.1 antirestriction protein -
Cf24236_RS21280 (Cf24236_4240) 4460921..4461400 + 480 WP_047358710.1 DNA repair protein RadC -
Cf24236_RS21285 (Cf24236_4241) 4461414..4461635 + 222 WP_047358709.1 DUF987 domain-containing protein -
Cf24236_RS21290 (Cf24236_4242) 4461657..4462022 + 366 WP_047358708.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
Cf24236_RS21295 (Cf24236_4243) 4462080..4462460 + 381 WP_047358707.1 TA system toxin CbtA family protein Toxin
Cf24236_RS21300 (Cf24236_4244) 4462457..4462948 + 492 WP_047358706.1 DUF5983 family protein -
Cf24236_RS26355 4463022..4463189 + 168 WP_072058785.1 DUF957 domain-containing protein -
Cf24236_RS21305 (Cf24236_4245) 4463270..4464118 + 849 WP_047358705.1 DUF4942 domain-containing protein -
Cf24236_RS21310 (Cf24236_4246) 4465092..4465748 + 657 WP_195296354.1 TetR/AcrR family transcriptional regulator -
Cf24236_RS21315 (Cf24236_4247) 4465806..4466789 - 984 WP_275257657.1 MDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14216.38 Da        Isoelectric Point: 10.0929

>T212813 WP_047358707.1 NZ_CP081314:4462080-4462460 [Citrobacter farmeri]
MQTLSAIPTRKAPSHPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEKIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS

Download         Length: 381 bp

>T212813 NZ_CP107367:c2765827-2764505 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13417.25 Da        Isoelectric Point: 6.4780

>AT212813 WP_047358708.1 NZ_CP081314:4461657-4462022 [Citrobacter farmeri]
MSNQLPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPALLKQLELMLVSGELN
PRHQHCVTLYAKGLTCEADSLGSHGYIYTAMYPTPDNSITR

Download         Length: 366 bp

>AT212813 NZ_CP107367:c2766093-2765827 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6TYH6

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6TXP6

References