Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3466823..3467487 Replicon chromosome
Accession NZ_CP081314
Organism Citrobacter farmeri strain CCRI-24236

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag Cf24236_RS16460 Protein ID WP_180208558.1
Coordinates 3467161..3467487 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag Cf24236_RS16455 Protein ID WP_222563673.1
Coordinates 3466823..3467140 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Cf24236_RS16410 (Cf24236_3269) 3462259..3463080 + 822 WP_222563667.1 DUF932 domain-containing protein -
Cf24236_RS16415 (Cf24236_3270) 3463297..3463998 + 702 WP_032654806.1 WYL domain-containing protein -
Cf24236_RS16420 (Cf24236_3271) 3464035..3464271 + 237 WP_001115854.1 protein YpjK -
Cf24236_RS16425 (Cf24236_3272) 3464271..3464714 + 444 WP_222563668.1 hypothetical protein -
Cf24236_RS16430 (Cf24236_3273) 3464737..3465204 + 468 WP_001547765.1 protein YkfB -
Cf24236_RS16435 (Cf24236_3274) 3465281..3465520 + 240 WP_222563669.1 DUF905 domain-containing protein -
Cf24236_RS16440 (Cf24236_3275) 3465622..3466080 + 459 WP_222563670.1 antirestriction protein -
Cf24236_RS16445 (Cf24236_3276) 3466096..3466572 + 477 WP_222563671.1 RadC family protein -
Cf24236_RS16450 (Cf24236_3277) 3466581..3466802 + 222 WP_222563672.1 DUF987 domain-containing protein -
Cf24236_RS16455 (Cf24236_3278) 3466823..3467140 + 318 WP_222563673.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
Cf24236_RS16460 (Cf24236_3279) 3467161..3467487 + 327 WP_180208558.1 TA system toxin CbtA family protein Toxin
Cf24236_RS16465 (Cf24236_3280) 3468237..3468788 + 552 WP_195617667.1 type IV secretion protein Rhs -
Cf24236_RS16470 (Cf24236_3281) 3468785..3469138 + 354 WP_195293282.1 hypothetical protein -
Cf24236_RS16480 3469244..3469440 - 197 Protein_3245 pyocin activator PrtN family protein -
Cf24236_RS16485 (Cf24236_3283) 3469697..3469990 - 294 WP_225934947.1 CPCC family cysteine-rich protein -
Cf24236_RS16490 (Cf24236_3284) 3470108..3470599 - 492 WP_195293281.1 LuxR C-terminal-related transcriptional regulator -
Cf24236_RS16495 (Cf24236_3285) 3470659..3471201 - 543 WP_195504336.1 hypothetical protein -
Cf24236_RS16500 (Cf24236_3286) 3471317..3471766 - 450 WP_044267717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3446021..3471766 25745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-106)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12347.29 Da        Isoelectric Point: 8.0567

>T212810 WP_180208558.1 NZ_CP081314:3467161-3467487 [Citrobacter farmeri]
MKTLPATISRATKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYIRAVDILRARQTLGLLRGSH

Download         Length: 327 bp

>T212810 NZ_CP107367:746778-747263 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12132.74 Da        Isoelectric Point: 7.3997

>AT212810 WP_222563673.1 NZ_CP081314:3466823-3467140 [Citrobacter farmeri]
MTHNTWGLQRDITPRLGARLVQERNRLHYLADRASITGKFSDAEYRKLDETFPHFIRQMESMLTTAELSPQHAHCVILYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT212810 NZ_CP107367:746470-746781 [Klebsiella pneumoniae]
CTGAAAACACAACCCGCTACGGGGGAGACTTACCCGAAATCTGATTTATTCAACAAAGCCAATCTGCGCATTAAACCTGC
CGAACGCGATCTTATTGATCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTG
CCGCTGAGGAAGCGCTGATTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGAT
CAGGCTCCTGCACCTAATGCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References