Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2449812..2451397 Replicon chromosome
Accession NZ_CP081314
Organism Citrobacter farmeri strain CCRI-24236

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag Cf24236_RS11655 Protein ID WP_196014188.1
Coordinates 2450078..2451397 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag Cf24236_RS11650 Protein ID WP_195293901.1
Coordinates 2449812..2450078 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Cf24236_RS11625 (Cf24236_2316) 2444847..2445614 + 768 WP_216525558.1 SDR family oxidoreductase -
Cf24236_RS11630 (Cf24236_2317) 2445698..2447059 + 1362 WP_195293905.1 MFS transporter -
Cf24236_RS11635 (Cf24236_2318) 2447028..2448119 + 1092 WP_222563824.1 L-idonate 5-dehydrogenase -
Cf24236_RS11640 (Cf24236_2319) 2448210..2448929 + 720 WP_195293903.1 FadR/GntR family transcriptional regulator -
Cf24236_RS11645 (Cf24236_2320) 2449002..2449613 - 612 WP_216525626.1 DJ-1/PfpI family protein -
Cf24236_RS11650 (Cf24236_2321) 2449812..2450078 + 267 WP_195293901.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
Cf24236_RS11655 (Cf24236_2322) 2450078..2451397 + 1320 WP_196014188.1 type II toxin-antitoxin system HipA family toxin Toxin
Cf24236_RS11660 (Cf24236_2323) 2451798..2453126 + 1329 WP_195293891.1 glycoside hydrolase family 10 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49004.63 Da        Isoelectric Point: 8.4345

>T212800 WP_196014188.1 NZ_CP081314:2450078-2451397 [Citrobacter farmeri]
MPKLVTWMNNQRVGELTKLANGAHTFKYASDWLANRYARPLSLSLPLQVGKITSDAVFNFFDNLLPDSPIVRDRIVKRYR
AKSKQPFDLLSEVGRDSVGAVTLLPENEAVTNPVMVWEKLSEAKLEEVLSAYKSDIPLGMINEENDFRISVAGAQEKTAL
LRMGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYFCLLLAKQLGLDVPGAEIIKAGRVRALAVERFDRRW
NAERSVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGRKTAIDKIYPRHFMATAKALKFPQEQMREILCKFAEQIP
AALDNVTAALPIDFPENVAMAIRSNVLRLHGRLNRETEE

Download         Length: 1320 bp

>T212800 NZ_CP107363:3274777-3275061 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10006.46 Da        Isoelectric Point: 4.6081

>AT212800 WP_195293901.1 NZ_CP081314:2449812-2450078 [Citrobacter farmeri]
MMSFPMIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLMTFFKILQSLELSMTLCETKDAAPES
TDQQSLEW

Download         Length: 267 bp

>AT212800 NZ_CP107363:3274545-3274787 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References