Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1192108..1192814 Replicon chromosome
Accession NZ_CP081314
Organism Citrobacter farmeri strain CCRI-24236

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag Cf24236_RS05745 Protein ID WP_079939377.1
Coordinates 1192446..1192814 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag Cf24236_RS05740 Protein ID WP_180256367.1
Coordinates 1192108..1192425 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Cf24236_RS05705 (Cf24236_1132) 1188171..1188572 - 402 WP_144812394.1 VOC family protein -
Cf24236_RS05710 (Cf24236_1133) 1188586..1189329 - 744 WP_144812391.1 SDR family oxidoreductase -
Cf24236_RS05715 (Cf24236_1134) 1189466..1190353 + 888 WP_144812388.1 AraC family transcriptional regulator -
Cf24236_RS05720 1190723..1190894 + 172 Protein_1126 hypothetical protein -
Cf24236_RS05725 (Cf24236_1135) 1190908..1191369 + 462 WP_180256368.1 antirestriction protein -
Cf24236_RS05730 (Cf24236_1136) 1191378..1191860 + 483 WP_032250314.1 DNA repair protein RadC -
Cf24236_RS05735 (Cf24236_1137) 1191869..1192090 + 222 WP_079939379.1 DUF987 domain-containing protein -
Cf24236_RS05740 (Cf24236_1138) 1192108..1192425 + 318 WP_180256367.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
Cf24236_RS05745 (Cf24236_1139) 1192446..1192814 + 369 WP_079939377.1 TA system toxin CbtA family protein Toxin
Cf24236_RS05750 (Cf24236_1140) 1193549..1194265 + 717 WP_195505878.1 YebC/PmpR family DNA-binding transcriptional regulator -
Cf24236_RS26270 (Cf24236_1142) 1194667..1194891 + 225 WP_225934977.1 hypothetical protein -
Cf24236_RS05755 (Cf24236_1143) 1195019..1196536 - 1518 WP_225934978.1 diguanylate cyclase DgcJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13838.97 Da        Isoelectric Point: 8.7453

>T212798 WP_079939377.1 NZ_CP081314:1192446-1192814 [Citrobacter farmeri]
MKTRPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFWDQTVIQEHIDAGITLANAVNFLVEKHELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ

Download         Length: 369 bp

>T212798 NZ_CP107363:2794409-2794792 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11857.48 Da        Isoelectric Point: 6.9459

>AT212798 WP_180256367.1 NZ_CP081314:1192108-1192425 [Citrobacter farmeri]
MNNTTWGLQRDITPRLGARLVQEGNRMHYLADRASITGKFSDAECLKLDVAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT212798 NZ_CP107363:2794167-2794409 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References