Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 44577..45178 | Replicon | plasmid pEc1079_2 |
| Accession | NZ_CP081308 | ||
| Organism | Escherichia coli strain Ec1079 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | K5A55_RS24050 | Protein ID | WP_074470340.1 |
| Coordinates | 44577..44957 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | V0AIN3 |
| Locus tag | K5A55_RS24055 | Protein ID | WP_001190708.1 |
| Coordinates | 44957..45178 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5A55_RS24015 (K5A55_24015) | 40457..41485 | + | 1029 | WP_221582574.1 | tyrosine-type recombinase/integrase | - |
| K5A55_RS24020 (K5A55_24020) | 41559..41903 | + | 345 | WP_260420032.1 | hypothetical protein | - |
| K5A55_RS24025 (K5A55_24025) | 41900..42376 | + | 477 | WP_221582575.1 | hypothetical protein | - |
| K5A55_RS24030 (K5A55_24030) | 42373..42867 | + | 495 | WP_000640907.1 | dUTP diphosphatase | - |
| K5A55_RS24035 (K5A55_24035) | 42882..43559 | + | 678 | WP_114447223.1 | DUF2829 domain-containing protein | - |
| K5A55_RS24040 (K5A55_24040) | 43566..44342 | + | 777 | WP_000432096.1 | hypothetical protein | - |
| K5A55_RS24045 (K5A55_24045) | 44375..44572 | - | 198 | WP_221582576.1 | PdcA protein | - |
| K5A55_RS24050 (K5A55_24050) | 44577..44957 | - | 381 | WP_074470340.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| K5A55_RS24055 (K5A55_24055) | 44957..45178 | - | 222 | WP_001190708.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| K5A55_RS24060 (K5A55_24060) | 45287..45709 | - | 423 | WP_000098854.1 | hypothetical protein | - |
| K5A55_RS24065 (K5A55_24065) | 45844..46233 | - | 390 | WP_000506729.1 | S24 family peptidase | - |
| K5A55_RS24070 (K5A55_24070) | 46293..46391 | - | 99 | Protein_48 | DNA polymerase III subunit theta | - |
| K5A55_RS24970 | 46424..46774 | + | 351 | WP_001436207.1 | hypothetical protein | - |
| K5A55_RS24080 (K5A55_24080) | 46759..47043 | - | 285 | WP_221582548.1 | antitoxin PHD | - |
| K5A55_RS24085 (K5A55_24085) | 47027..48049 | - | 1023 | WP_221582549.1 | hypothetical protein | - |
| K5A55_RS24090 (K5A55_24090) | 48060..48323 | - | 264 | WP_000224227.1 | hypothetical protein | - |
| K5A55_RS24095 (K5A55_24095) | 48325..48519 | - | 195 | WP_000224731.1 | hypothetical protein | - |
| K5A55_RS24100 (K5A55_24100) | 48521..49246 | - | 726 | WP_221582550.1 | ead/Ea22-like family protein | - |
| K5A55_RS24105 (K5A55_24105) | 49243..49482 | - | 240 | WP_000476201.1 | hypothetical protein | - |
| K5A55_RS24110 (K5A55_24110) | 49475..49678 | - | 204 | WP_000158003.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..90661 | 90661 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13691.42 Da Isoelectric Point: 5.1514
>T212796 WP_074470340.1 NZ_CP081308:c44957-44577 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVYSVADTLRRLYGSAE
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVYSVADTLRRLYGSAE
Download Length: 381 bp
>T212796 NZ_CP107363:c2362095-2361748 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8147.17 Da Isoelectric Point: 5.1106
>AT212796 WP_001190708.1 NZ_CP081308:c45178-44957 [Escherichia coli]
MQSINFRTARGKLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGKLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT212796 NZ_CP107363:c2361748-2361449 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|