Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2847072..2847916 Replicon chromosome
Accession NZ_CP081306
Organism Escherichia coli strain Ec1079

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag K5A55_RS13925 Protein ID WP_000854686.1
Coordinates 2847072..2847455 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag K5A55_RS13930 Protein ID WP_001285602.1
Coordinates 2847536..2847916 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5A55_RS13885 (2842075) 2842075..2842566 - 492 WP_001297187.1 DUF1097 domain-containing protein -
K5A55_RS13890 (2842668) 2842668..2843222 - 555 WP_001001902.1 molecular chaperone YcdY -
K5A55_RS13895 (2843246) 2843246..2843983 - 738 WP_000283664.1 zinc-binding phosphatase -
K5A55_RS13900 (2844038) 2844038..2844976 - 939 WP_000351311.1 glyoxylate/hydroxypyruvate reductase GhrA -
K5A55_RS13910 (2845447) 2845447..2846288 - 842 Protein_2726 DUF4942 domain-containing protein -
K5A55_RS13915 (2846373) 2846373..2846570 - 198 WP_000839253.1 DUF957 domain-containing protein -
K5A55_RS13920 (2846587) 2846587..2847075 - 489 WP_032180032.1 DUF5983 family protein -
K5A55_RS13925 (2847072) 2847072..2847455 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
K5A55_RS13930 (2847536) 2847536..2847916 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K5A55_RS13935 (2847927) 2847927..2848610 - 684 WP_000086768.1 hypothetical protein -
K5A55_RS13940 (2848629) 2848629..2848850 - 222 WP_000692298.1 DUF987 domain-containing protein -
K5A55_RS13945 (2848913) 2848913..2849389 - 477 WP_001186726.1 RadC family protein -
K5A55_RS13950 (2849405) 2849405..2849890 - 486 WP_000214307.1 antirestriction protein -
K5A55_RS13955 (2849982) 2849982..2850803 - 822 WP_001761104.1 DUF932 domain-containing protein -
K5A55_RS13960 (2850904) 2850904..2851112 - 209 Protein_2736 DUF905 domain-containing protein -
K5A55_RS13965 (2851213) 2851213..2851668 - 456 WP_000581506.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T212786 WP_000854686.1 NZ_CP081306:c2847455-2847072 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T212786 NZ_CP107359:c4797150-4796617 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT212786 WP_001285602.1 NZ_CP081306:c2847916-2847536 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT212786 NZ_CP107359:c4797427-4797161 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References