Detailed information of TA system TA212761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4639600..4640858
• Replicon: chromosome
• Accession: NZ_CP081287
• Organism: Pseudomonas aeruginosa strain F092021

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: K3T18_RS21765
• Protein ID: WP_023109087.1
• Coordinates: 4639600..4640355 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: K3T18_RS21770
• Protein ID: WP_003086329.1
• Coordinates: 4640490..4640858 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3T18_RS21755 (K3T18_21755)	4634772..4637315	+	2544	WP_221345426.1	acyl-homoserine-lactone acylase QuiP	-
K3T18_RS21760 (K3T18_21760)	4637470..4638831	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
K3T18_RS21765 (K3T18_21765)	4639600..4640355	-	756	WP_023109087.1	RES family NAD+ phosphorylase	Toxin
K3T18_RS21770 (K3T18_21770)	4640490..4640858	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
K3T18_RS21775 (K3T18_21775)	4640931..4642217	-	1287	WP_054376095.1	FAD-binding oxidoreductase	-
K3T18_RS21780 (K3T18_21780)	4642273..4643862	-	1590	WP_023464367.1	aldehyde dehydrogenase family protein	-
K3T18_RS21785 (K3T18_21785)	4643941..4644417	+	477	WP_004353334.1	elongation factor GreAB	-
K3T18_RS21790 (K3T18_21790)	4644420..4644695	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28264.40 Da
• Isoelectric Point: 7.7294

>T212761 WP_023109087.1 NZ_CP081287:c4640355-4639600 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T212761 NZ_CP107352:c1187262-1186945 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT212761 WP_003086329.1 NZ_CP081287:c4640858-4640490 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT212761 NZ_CP107352:c1186952-1186665 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Antitoxin

• AlphaFold DB: V6AJU7