Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 179317..179822 Replicon chromosome
Accession NZ_CP081287
Organism Pseudomonas aeruginosa strain F092021

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag K3T18_RS00810 Protein ID WP_003083773.1
Coordinates 179317..179598 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag K3T18_RS00815 Protein ID WP_003083775.1
Coordinates 179595..179822 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3T18_RS00785 (K3T18_00785) 174568..175917 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
K3T18_RS00790 (K3T18_00790) 175966..176652 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
K3T18_RS00795 (K3T18_00795) 176753..177487 + 735 WP_003117208.1 GntR family transcriptional regulator -
K3T18_RS00800 (K3T18_00800) 177667..178077 + 411 WP_003101225.1 aegerolysin family protein -
K3T18_RS00805 (K3T18_00805) 178109..179017 - 909 WP_023132709.1 LysR family transcriptional regulator -
K3T18_RS00810 (K3T18_00810) 179317..179598 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
K3T18_RS00815 (K3T18_00815) 179595..179822 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
K3T18_RS00820 (K3T18_00820) 179998..180618 - 621 WP_003101226.1 hypothetical protein -
K3T18_RS00825 (K3T18_00825) 180719..181219 + 501 WP_003101228.1 LEA type 2 family protein -
K3T18_RS00830 (K3T18_00830) 181292..181633 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
K3T18_RS00835 (K3T18_00835) 181715..183142 - 1428 WP_003083784.1 GABA permease -
K3T18_RS00840 (K3T18_00840) 183311..184804 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T212758 WP_003083773.1 NZ_CP081287:c179598-179317 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T212758 NZ_CP107350:c4371-4057 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT212758 WP_003083775.1 NZ_CP081287:c179822-179595 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT212758 NZ_CP107350:c4637-4359 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References