Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 104764..105680 Replicon plasmid unnamed1
Accession NZ_CP081203
Organism Pseudomonas aeruginosa strain P9W

Toxin (Protein)


Gene name slvT Uniprot ID A0A212BIN6
Locus tag K3176_RS34985 Protein ID WP_021018402.1
Coordinates 105156..105680 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2I0C738
Locus tag K3176_RS34980 Protein ID WP_010792483.1
Coordinates 104764..105159 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3176_RS34965 (K3176_34965) 100787..101311 - 525 WP_010792479.1 hypothetical protein -
K3176_RS34970 (K3176_34970) 102190..102471 - 282 WP_010792481.1 hypothetical protein -
K3176_RS34975 (K3176_34975) 102620..104554 + 1935 WP_021018401.1 hypothetical protein -
K3176_RS34980 (K3176_34980) 104764..105159 + 396 WP_010792483.1 hypothetical protein Antitoxin
K3176_RS34985 (K3176_34985) 105156..105680 + 525 WP_021018402.1 RES family NAD+ phosphorylase Toxin
K3176_RS34990 (K3176_34990) 105726..106976 - 1251 WP_010792484.1 TerD family protein -
K3176_RS34995 (K3176_34995) 107173..108228 - 1056 WP_021018403.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
K3176_RS35000 (K3176_35000) 108606..108797 + 192 WP_010792486.1 hypothetical protein -
K3176_RS35005 (K3176_35005) 109219..110364 - 1146 WP_021018404.1 glycerate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaKPC-2 / sul1 / qacE / cmlA1 / ant(2'')-Ia - 1..475028 475028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19011.47 Da        Isoelectric Point: 4.4540

>T212750 WP_021018402.1 NZ_CP081203:105156-105680 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T212750 NZ_CP107345:c4884123-4883839 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14810.93 Da        Isoelectric Point: 7.2048

>AT212750 WP_010792483.1 NZ_CP081203:104764-105159 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT212750 NZ_CP107345:c4884355-4884113 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A212BIN6

Antitoxin

Source ID Structure
AlphaFold DB A0A2I0C738

References