Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5482034..5482539 Replicon chromosome
Accession NZ_CP081202
Organism Pseudomonas aeruginosa strain P9W

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag K3176_RS26460 Protein ID WP_003083773.1
Coordinates 5482258..5482539 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag K3176_RS26455 Protein ID WP_003083775.1
Coordinates 5482034..5482261 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3176_RS26430 (K3176_26430) 5477052..5478545 + 1494 WP_016263977.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
K3176_RS26435 (K3176_26435) 5478714..5480141 + 1428 WP_003083784.1 GABA permease -
K3176_RS26440 (K3176_26440) 5480223..5480564 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
K3176_RS26445 (K3176_26445) 5480637..5481137 - 501 WP_003112629.1 LEA type 2 family protein -
K3176_RS26450 (K3176_26450) 5481238..5481858 + 621 WP_003101226.1 hypothetical protein -
K3176_RS26455 (K3176_26455) 5482034..5482261 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
K3176_RS26460 (K3176_26460) 5482258..5482539 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
K3176_RS26465 (K3176_26465) 5482839..5483747 + 909 WP_003083769.1 LysR family transcriptional regulator -
K3176_RS26470 (K3176_26470) 5483779..5484189 - 411 WP_003101225.1 aegerolysin family protein -
K3176_RS26475 (K3176_26475) 5484369..5485103 - 735 WP_003117208.1 GntR family transcriptional regulator -
K3176_RS26480 (K3176_26480) 5485204..5485890 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
K3176_RS26485 (K3176_26485) 5485939..5487288 - 1350 WP_023910702.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T212746 WP_003083773.1 NZ_CP081202:5482258-5482539 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T212746 NZ_CP107345:2009758-2009860 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT212746 WP_003083775.1 NZ_CP081202:5482034-5482261 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT212746 NZ_CP107345:c2009867-2009722 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References