Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2935319..2936361 Replicon chromosome
Accession NZ_CP081202
Organism Pseudomonas aeruginosa strain P9W

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag K3176_RS14005 Protein ID WP_003153636.1
Coordinates 2935319..2935894 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag K3176_RS14010 Protein ID WP_003050245.1
Coordinates 2935891..2936361 (-) Length 157 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3176_RS13980 (K3176_13980) 2931757..2932482 - 726 WP_003050273.1 CBASS effector endonuclease NucC -
K3176_RS13985 (K3176_13985) 2932521..2933423 - 903 WP_003090158.1 CBASS oligonucleotide cyclase -
K3176_RS13990 (K3176_13990) 2933423..2933923 - 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
K3176_RS13995 (K3176_13995) 2933920..2934390 - 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
K3176_RS14000 (K3176_14000) 2934387..2935301 - 915 WP_016852809.1 AAA family ATPase -
K3176_RS14005 (K3176_14005) 2935319..2935894 - 576 WP_003153636.1 PIN domain-containing protein Toxin
K3176_RS14010 (K3176_14010) 2935891..2936361 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
K3176_RS14015 (K3176_14015) 2936565..2936948 + 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
K3176_RS14020 (K3176_14020) 2936945..2937178 + 234 WP_003090170.1 TIGR03758 family integrating conjugative element protein -
K3176_RS14025 (K3176_14025) 2937195..2937554 + 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
K3176_RS14030 (K3176_14030) 2937566..2937964 + 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
K3176_RS14035 (K3176_14035) 2937961..2938653 + 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
K3176_RS14040 (K3176_14040) 2938650..2939561 + 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
K3176_RS14045 (K3176_14045) 2939551..2940969 + 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2885788..2990775 104987


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-114)

Antitoxin

(85-133)


Sequences


Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T212744 WP_003153636.1 NZ_CP081202:c2935894-2935319 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

>T212744 NZ_CP107345:744113-744598 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT212744 WP_003050245.1 NZ_CP081202:c2936361-2935891 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp

>AT212744 NZ_CP107345:743823-744116 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References