Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1911334..1911915 Replicon chromosome
Accession NZ_CP081201
Organism Pseudomonas phytophila strain ICMP 23753

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K3169_RS08575 Protein ID WP_027899161.1
Coordinates 1911622..1911915 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K3169_RS08570 Protein ID WP_099269095.1
Coordinates 1911334..1911618 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3169_RS08530 (K3169_08490) 1906589..1907704 + 1116 WP_231665666.1 outer membrane protein assembly factor BamC -
K3169_RS08535 (K3169_08495) 1907705..1908463 + 759 WP_027899152.1 MBL fold metallo-hydrolase -
K3169_RS08540 (K3169_08500) 1908492..1909205 + 714 WP_077571533.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
K3169_RS08550 (K3169_08510) 1909520..1909915 + 396 WP_231675575.1 nucleotidyltransferase domain-containing protein -
K3169_RS08555 (K3169_08515) 1909905..1910327 + 423 WP_231675574.1 DUF86 domain-containing protein -
K3169_RS08560 (K3169_08520) 1910841..1911068 + 228 WP_099269093.1 hypothetical protein -
K3169_RS08565 (K3169_08525) 1911065..1911271 - 207 WP_099269094.1 hypothetical protein -
K3169_RS08570 (K3169_08530) 1911334..1911618 - 285 WP_099269095.1 putative addiction module antidote protein Antitoxin
K3169_RS08575 (K3169_08535) 1911622..1911915 - 294 WP_027899161.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K3169_RS08580 (K3169_08540) 1912252..1912902 - 651 WP_263271022.1 HAD-IA family hydrolase -
K3169_RS08585 (K3169_08545) 1913272..1914960 + 1689 WP_099269098.1 NAD-dependent malic enzyme -
K3169_RS08590 (K3169_08550) 1915332..1915868 + 537 Protein_1701 methylated-DNA--[protein]-cysteine S-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1909905..1921474 11569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(5-89)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10783.42 Da        Isoelectric Point: 10.6100

>T212738 WP_027899161.1 NZ_CP081201:c1911915-1911622 [Pseudomonas phytophila]
VTYTIQQTQIFTHWHAGLRDIRARIAIARRIERVSAGNLGDVKAVGEGVSEMRVDVGAGYRIYFTTRDRTIIVLLVGGDK
STQPGDIRQAKIMAKEV

Download         Length: 294 bp

>T212738 NZ_CP107342:c45309-45160 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 9977.58 Da        Isoelectric Point: 7.2012

>AT212738 WP_099269095.1 NZ_CP081201:c1911618-1911334 [Pseudomonas phytophila]
MSTTLVPFDMAAILDSDEAINEYLSQVLADGDTDELIRAVGHVAKARGMAQIAKDSGLGRASLYKALAPGAKPRFDTVLK
VLTALGIKLVTHRP

Download         Length: 285 bp

>AT212738 NZ_CP107342:45354-45413 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References