Detailed information of TA system TA212737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 1487619..1488208
• Replicon: chromosome
• Accession: NZ_CP081201
• Organism: Pseudomonas phytophila strain ICMP 23753

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K3169_RS06560
• Protein ID: WP_099268543.1
• Coordinates: 1487957..1488208 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K3169_RS06555
• Protein ID: WP_122398368.1
• Coordinates: 1487619..1487960 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3169_RS06525 (K3169_06485)	1483141..1483863	-	723	WP_122398366.1	urea carboxylase-associated family protein	-
K3169_RS06530 (K3169_06490)	1483876..1484649	-	774	WP_263270686.1	ABC transporter ATP-binding protein	-
K3169_RS06535 (K3169_06495)	1484646..1485461	-	816	WP_027899755.1	ABC transporter permease	-
K3169_RS06540 (K3169_06500)	1485489..1486559	-	1071	WP_122708026.1	putative urea ABC transporter substrate-binding protein	-
K3169_RS06545 (K3169_06505)	1486787..1487041	-	255	WP_263270689.1	hypothetical protein	-
K3169_RS06550 (K3169_06510)	1487019..1487519	+	501	WP_231677808.1	hypothetical protein	-
K3169_RS06555 (K3169_06515)	1487619..1487960	-	342	WP_122398368.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K3169_RS06560 (K3169_06520)	1487957..1488208	-	252	WP_099268543.1	type II toxin-antitoxin system HicA family toxin	Toxin
K3169_RS06565 (K3169_06525)	1488295..1489407	-	1113	WP_263270692.1	enoyl-CoA hydratase/isomerase family protein	-
K3169_RS06570 (K3169_06530)	1489572..1490264	+	693	WP_263270694.1	uracil-DNA glycosylase	-
K3169_RS06575 (K3169_06535)	1490359..1491393	-	1035	WP_263270696.1	AbrB family transcriptional regulator	-
K3169_RS06580 (K3169_06540)	1491386..1492900	-	1515	WP_027899762.1	tripartite tricarboxylate transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9271.77 Da
• Isoelectric Point: 10.5914

>T212737 WP_099268543.1 NZ_CP081201:c1488208-1487957 [Pseudomonas phytophila]
MSKQEKLLAKLLNRQSGFSWPELVALLKGFGYKQIEGDGSRVKFDNGNAQAMINLHRPHPGNEIKAYVKRQVIEHLKAGG
LIS

Nucleotide

• Length: 252 bp

>T212737 NZ_CP107341:4856120-4856222 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12573.06 Da
• Isoelectric Point: 5.9650

>AT212737 WP_122398368.1 NZ_CP081201:c1487960-1487619 [Pseudomonas phytophila]
MSTLLQHRGYYGSIEASPEDNCLFGKLQFIRALVNYEGETVAELSQSFRNAVDDYLDTCSTLGQDPELPCKGSFNVRVGH
DLHLAASVAATRDKISLNDLTRKALREYLSHHA

Nucleotide

• Length: 342 bp

>AT212737 NZ_CP107341:c4856229-4856084 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT