Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 1487619..1488208 Replicon chromosome
Accession NZ_CP081201
Organism Pseudomonas phytophila strain ICMP 23753

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K3169_RS06560 Protein ID WP_099268543.1
Coordinates 1487957..1488208 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K3169_RS06555 Protein ID WP_122398368.1
Coordinates 1487619..1487960 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3169_RS06525 (K3169_06485) 1483141..1483863 - 723 WP_122398366.1 urea carboxylase-associated family protein -
K3169_RS06530 (K3169_06490) 1483876..1484649 - 774 WP_263270686.1 ABC transporter ATP-binding protein -
K3169_RS06535 (K3169_06495) 1484646..1485461 - 816 WP_027899755.1 ABC transporter permease -
K3169_RS06540 (K3169_06500) 1485489..1486559 - 1071 WP_122708026.1 putative urea ABC transporter substrate-binding protein -
K3169_RS06545 (K3169_06505) 1486787..1487041 - 255 WP_263270689.1 hypothetical protein -
K3169_RS06550 (K3169_06510) 1487019..1487519 + 501 WP_231677808.1 hypothetical protein -
K3169_RS06555 (K3169_06515) 1487619..1487960 - 342 WP_122398368.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K3169_RS06560 (K3169_06520) 1487957..1488208 - 252 WP_099268543.1 type II toxin-antitoxin system HicA family toxin Toxin
K3169_RS06565 (K3169_06525) 1488295..1489407 - 1113 WP_263270692.1 enoyl-CoA hydratase/isomerase family protein -
K3169_RS06570 (K3169_06530) 1489572..1490264 + 693 WP_263270694.1 uracil-DNA glycosylase -
K3169_RS06575 (K3169_06535) 1490359..1491393 - 1035 WP_263270696.1 AbrB family transcriptional regulator -
K3169_RS06580 (K3169_06540) 1491386..1492900 - 1515 WP_027899762.1 tripartite tricarboxylate transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9271.77 Da        Isoelectric Point: 10.5914

>T212737 WP_099268543.1 NZ_CP081201:c1488208-1487957 [Pseudomonas phytophila]
MSKQEKLLAKLLNRQSGFSWPELVALLKGFGYKQIEGDGSRVKFDNGNAQAMINLHRPHPGNEIKAYVKRQVIEHLKAGG
LIS

Download         Length: 252 bp

>T212737 NZ_CP107341:4856120-4856222 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12573.06 Da        Isoelectric Point: 5.9650

>AT212737 WP_122398368.1 NZ_CP081201:c1487960-1487619 [Pseudomonas phytophila]
MSTLLQHRGYYGSIEASPEDNCLFGKLQFIRALVNYEGETVAELSQSFRNAVDDYLDTCSTLGQDPELPCKGSFNVRVGH
DLHLAASVAATRDKISLNDLTRKALREYLSHHA

Download         Length: 342 bp

>AT212737 NZ_CP107341:c4856229-4856084 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References