Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1446885..1447497 Replicon chromosome
Accession NZ_CP081201
Organism Pseudomonas phytophila strain ICMP 23753

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K3169_RS06385 Protein ID WP_263270654.1
Coordinates 1447315..1447497 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K3169_RS06380 Protein ID WP_122708054.1
Coordinates 1446885..1447292 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3169_RS06350 (K3169_06310) 1442256..1442861 + 606 WP_049827079.1 DUF2313 domain-containing protein -
K3169_RS06355 (K3169_06315) 1442861..1443964 + 1104 WP_263270648.1 phage tail protein -
K3169_RS06360 (K3169_06320) 1444148..1445230 + 1083 WP_263272235.1 phage tail protein -
K3169_RS06365 (K3169_06325) 1445239..1445808 + 570 WP_263270650.1 tail fiber assembly protein -
K3169_RS06370 (K3169_06330) 1445897..1446334 + 438 WP_263270651.1 cell wall hydrolase -
K3169_RS06375 (K3169_06335) 1446331..1446825 + 495 WP_263270653.1 lysis protein -
K3169_RS06380 (K3169_06340) 1446885..1447292 - 408 WP_122708054.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K3169_RS06385 (K3169_06345) 1447315..1447497 - 183 WP_263270654.1 type II toxin-antitoxin system HicA family toxin Toxin
K3169_RS06390 (K3169_06350) 1448059..1448880 - 822 WP_263270656.1 alpha/beta hydrolase -
K3169_RS06395 (K3169_06355) 1449527..1450381 + 855 WP_263270657.1 suppressor of fused domain protein -
K3169_RS06400 (K3169_06360) 1450676..1451566 - 891 WP_027901660.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1429694..1463463 33769


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6843.93 Da        Isoelectric Point: 10.5257

>T212736 WP_263270654.1 NZ_CP081201:c1447497-1447315 [Pseudomonas phytophila]
MRSREMIKAIEDDGWYLVASKGSYRQYKHATKPGRVTVKHPDSDIPIKTINSILKQSGLK

Download         Length: 183 bp

>T212736 NZ_CP107341:3671956-3672363 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14778.73 Da        Isoelectric Point: 4.9171

>AT212736 WP_122708054.1 NZ_CP081201:c1447292-1446885 [Pseudomonas phytophila]
MKFTVVLHKDADSDYGVIVPDVPGCFSAGSSVIEALDNVQEALSLHFEGLVEDGHPLPSPKAIDVHIANPDYAGGIWAVV
EFDVTPYFGKAVRFNATLPENLLMRIDDRVKNDHRYASRSGFLAAAALKELRCEH

Download         Length: 408 bp

>AT212736 NZ_CP107341:3671709-3671975 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References