Detailed information of TA system TA212736

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1446885..1447497
• Replicon: chromosome
• Accession: NZ_CP081201
• Organism: Pseudomonas phytophila strain ICMP 23753

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K3169_RS06385
• Protein ID: WP_263270654.1
• Coordinates: 1447315..1447497 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K3169_RS06380
• Protein ID: WP_122708054.1
• Coordinates: 1446885..1447292 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3169_RS06350 (K3169_06310)	1442256..1442861	+	606	WP_049827079.1	DUF2313 domain-containing protein	-
K3169_RS06355 (K3169_06315)	1442861..1443964	+	1104	WP_263270648.1	phage tail protein	-
K3169_RS06360 (K3169_06320)	1444148..1445230	+	1083	WP_263272235.1	phage tail protein	-
K3169_RS06365 (K3169_06325)	1445239..1445808	+	570	WP_263270650.1	tail fiber assembly protein	-
K3169_RS06370 (K3169_06330)	1445897..1446334	+	438	WP_263270651.1	cell wall hydrolase	-
K3169_RS06375 (K3169_06335)	1446331..1446825	+	495	WP_263270653.1	lysis protein	-
K3169_RS06380 (K3169_06340)	1446885..1447292	-	408	WP_122708054.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K3169_RS06385 (K3169_06345)	1447315..1447497	-	183	WP_263270654.1	type II toxin-antitoxin system HicA family toxin	Toxin
K3169_RS06390 (K3169_06350)	1448059..1448880	-	822	WP_263270656.1	alpha/beta hydrolase	-
K3169_RS06395 (K3169_06355)	1449527..1450381	+	855	WP_263270657.1	suppressor of fused domain protein	-
K3169_RS06400 (K3169_06360)	1450676..1451566	-	891	WP_027901660.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1429694..1463463	33769

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6843.93 Da
• Isoelectric Point: 10.5257

>T212736 WP_263270654.1 NZ_CP081201:c1447497-1447315 [Pseudomonas phytophila]
MRSREMIKAIEDDGWYLVASKGSYRQYKHATKPGRVTVKHPDSDIPIKTINSILKQSGLK

Nucleotide

• Length: 183 bp

>T212736 NZ_CP107341:3671956-3672363 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14778.73 Da
• Isoelectric Point: 4.9171

>AT212736 WP_122708054.1 NZ_CP081201:c1447292-1446885 [Pseudomonas phytophila]
MKFTVVLHKDADSDYGVIVPDVPGCFSAGSSVIEALDNVQEALSLHFEGLVEDGHPLPSPKAIDVHIANPDYAGGIWAVV
EFDVTPYFGKAVRFNATLPENLLMRIDDRVKNDHRYASRSGFLAAAALKELRCEH

Nucleotide

• Length: 408 bp

>AT212736 NZ_CP107341:3671709-3671975 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA