Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1795645..1796261 Replicon chromosome
Accession NZ_CP081200
Organism Pseudomonas sp. 3-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K3819_RS08165 Protein ID WP_085611511.1
Coordinates 1795645..1795857 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K3819_RS08170 Protein ID WP_221398988.1
Coordinates 1795857..1796261 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3819_RS08140 (K3819_08140) 1790788..1792776 + 1989 WP_221398986.1 heme lyase CcmF/NrfE family subunit -
K3819_RS08145 (K3819_08145) 1792773..1793309 + 537 WP_085611514.1 DsbE family thiol:disulfide interchange protein -
K3819_RS08150 (K3819_08150) 1793306..1793776 + 471 WP_064378637.1 cytochrome c-type biogenesis protein CcmH -
K3819_RS08155 (K3819_08155) 1793773..1794975 + 1203 WP_221398987.1 c-type cytochrome biogenesis protein CcmI -
K3819_RS08160 (K3819_08160) 1795001..1795408 + 408 WP_085611512.1 hypothetical protein -
K3819_RS08165 (K3819_08165) 1795645..1795857 + 213 WP_085611511.1 type II toxin-antitoxin system HicA family toxin Toxin
K3819_RS08170 (K3819_08170) 1795857..1796261 + 405 WP_221398988.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K3819_RS08175 (K3819_08175) 1796308..1797495 - 1188 WP_085611510.1 MFS transporter -
K3819_RS08180 (K3819_08180) 1797737..1798357 + 621 WP_221398989.1 DUF5666 domain-containing protein -
K3819_RS08185 (K3819_08185) 1798412..1799410 - 999 WP_221398990.1 sulfate ABC transporter substrate-binding protein -
K3819_RS08190 (K3819_08190) 1799516..1800340 - 825 WP_039769763.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8018.18 Da        Isoelectric Point: 10.4352

>T212733 WP_085611511.1 NZ_CP081200:1795645-1795857 [Pseudomonas sp. 3-2]
VQSRLLIKELEEAGWTLDRITGSHHIFTHRYNPYTIPVPHPKKDLPVGTVKSIRRRAGLYNPPASYRGDP

Download         Length: 213 bp

>T212733 NZ_CP107341:c2717247-2716864 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14862.87 Da        Isoelectric Point: 4.3841

>AT212733 WP_221398988.1 NZ_CP081200:1795857-1796261 [Pseudomonas sp. 3-2]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDTFEDAYNAAVEIAHIMLQEIAADGDLIPMPTSAATHRNNPEFADMGWGM
LELDISPYMGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRH

Download         Length: 405 bp

>AT212733 NZ_CP107341:c2717489-2717247 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References