Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 328924..329563 | Replicon | chromosome |
| Accession | NZ_CP081200 | ||
| Organism | Pseudomonas sp. 3-2 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A2N7RHC6 |
| Locus tag | K3819_RS01470 | Protein ID | WP_041071532.1 |
| Coordinates | 328924..329106 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | K3819_RS01475 | Protein ID | WP_221398500.1 |
| Coordinates | 329138..329563 (+) | Length | 142 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3819_RS01435 (K3819_01435) | 324013..324729 | + | 717 | WP_074689485.1 | AzlC family ABC transporter permease | - |
| K3819_RS01440 (K3819_01440) | 324708..325025 | + | 318 | WP_007952614.1 | AzlD domain-containing protein | - |
| K3819_RS01445 (K3819_01445) | 324942..325868 | - | 927 | WP_011331998.1 | LysR family transcriptional regulator | - |
| K3819_RS01450 (K3819_01450) | 326539..326757 | + | 219 | WP_007952610.1 | 4-oxalocrotonate tautomerase family protein | - |
| K3819_RS01455 (K3819_01455) | 326754..327398 | + | 645 | WP_221398498.1 | DsbA family oxidoreductase | - |
| K3819_RS01460 (K3819_01460) | 327432..328142 | + | 711 | WP_221398499.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| K3819_RS01465 (K3819_01465) | 328201..328467 | - | 267 | WP_085702718.1 | DUF3077 domain-containing protein | - |
| K3819_RS01470 (K3819_01470) | 328924..329106 | + | 183 | WP_041071532.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K3819_RS01475 (K3819_01475) | 329138..329563 | + | 426 | WP_221398500.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K3819_RS01485 (K3819_01485) | 329845..330660 | - | 816 | WP_085647974.1 | FkbM family methyltransferase | - |
| K3819_RS01490 (K3819_01490) | 331005..332240 | - | 1236 | WP_221398501.1 | methyltransferase | - |
| K3819_RS01495 (K3819_01495) | 332221..332910 | - | 690 | WP_039764656.1 | ABC transporter permease | - |
| K3819_RS01500 (K3819_01500) | 332907..333602 | - | 696 | WP_085611179.1 | ABC transporter permease | - |
| K3819_RS01505 (K3819_01505) | 333681..334427 | - | 747 | WP_064592811.1 | ABC transporter substrate-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6782.85 Da Isoelectric Point: 10.7304
>T212730 WP_041071532.1 NZ_CP081200:328924-329106 [Pseudomonas sp. 3-2]
MKYSEFRRWLKAQGVEFQTGKGSHFKVSLNGKSTVFPDHGAKEMGEGLRKSIIKQLGLKD
MKYSEFRRWLKAQGVEFQTGKGSHFKVSLNGKSTVFPDHGAKEMGEGLRKSIIKQLGLKD
Download Length: 183 bp
>T212730 NZ_CP107341:c2051863-2051330 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 142 a.a. Molecular weight: 15456.53 Da Isoelectric Point: 4.3686
>AT212730 WP_221398500.1 NZ_CP081200:329138-329563 [Pseudomonas sp. 3-2]
MFEYALEVHEEPGSVWLSCAEIPEMHAAGDTLEEALDGAIDAMETALSIYVDDRRLIPTGDAGEQESDAVLRLPALTAAK
VGLWNALLESGVSKAELARRLGVQRPQVDRLVDFLHHSKIENVERALQQLGRRILLSVEAA
MFEYALEVHEEPGSVWLSCAEIPEMHAAGDTLEEALDGAIDAMETALSIYVDDRRLIPTGDAGEQESDAVLRLPALTAAK
VGLWNALLESGVSKAELARRLGVQRPQVDRLVDFLHHSKIENVERALQQLGRRILLSVEAA
Download Length: 426 bp
>AT212730 NZ_CP107341:c2052140-2051874 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|