Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 182466..182982 Replicon chromosome
Accession NZ_CP081200
Organism Pseudomonas sp. 3-2

Toxin (Protein)


Gene name relE Uniprot ID A0A0C1WG29
Locus tag K3819_RS00795 Protein ID WP_039773012.1
Coordinates 182701..182982 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C1VYZ2
Locus tag K3819_RS00790 Protein ID WP_039773014.1
Coordinates 182466..182711 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3819_RS00765 (K3819_00765) 178428..180008 + 1581 WP_085613327.1 glycosyltransferase family 39 protein -
K3819_RS00770 (K3819_00770) 180053..180811 - 759 WP_039773021.1 slipin family protein -
K3819_RS00775 (K3819_00775) 180814..181341 - 528 WP_221398450.1 NfeD family protein -
K3819_RS00780 (K3819_00780) 181538..181999 + 462 WP_007957669.1 YbaK/EbsC family protein -
K3819_RS00785 (K3819_00785) 182128..182370 + 243 WP_221398451.1 DUF2789 domain-containing protein -
K3819_RS00790 (K3819_00790) 182466..182711 + 246 WP_039773014.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K3819_RS00795 (K3819_00795) 182701..182982 + 282 WP_039773012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K3819_RS00800 (K3819_00800) 183107..183535 + 429 WP_039773010.1 winged helix DNA-binding protein -
K3819_RS00805 (K3819_00805) 183532..185595 + 2064 WP_221398452.1 FUSC family protein -
K3819_RS00810 (K3819_00810) 185592..185801 + 210 WP_007957657.1 DUF1656 domain-containing protein -
K3819_RS00815 (K3819_00815) 185798..186685 + 888 WP_163973805.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-67)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10971.80 Da        Isoelectric Point: 10.4588

>T212729 WP_039773012.1 NZ_CP081200:182701-182982 [Pseudomonas sp. 3-2]
MTYKLEFLPSAHKEWNKLGHTLRDQFKKKLAERLERPRIPADSLHGMPDCYKIKLKASGYRLVYQVIEERVVVSVVAVGK
RERSDVYENAKRR

Download         Length: 282 bp

>T212729 NZ_CP107341:1439041-1439259 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8776.06 Da        Isoelectric Point: 4.4988

>AT212729 WP_039773014.1 NZ_CP081200:182466-182711 [Pseudomonas sp. 3-2]
MQSVLADMAVSVSELKKNPSAVLNGAHGGAVAVLNHNRVMGYMVPADVYEAMMERLDDLELAEIVRSRSHETPIPVSLDD
L

Download         Length: 246 bp

>AT212729 NZ_CP107341:1438640-1439014 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C1WG29

Antitoxin

Source ID Structure
AlphaFold DB A0A0C1VYZ2

References