Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 6836..7337 | Replicon | plasmid unnamed5 |
| Accession | NZ_CP081196 | ||
| Organism | Escherichia coli strain EC1722-1 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | A0A6X6XTU7 |
| Locus tag | K4F91_RS26260 | Protein ID | WP_000702245.1 |
| Coordinates | 6836..7096 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | K4F91_RS26265 | Protein ID | WP_001132407.1 |
| Coordinates | 7086..7337 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K4F91_RS26215 (K4F91_26215) | 2078..2239 | + | 162 | WP_001128311.1 | hypothetical protein | - |
| K4F91_RS26925 | 2375..2527 | + | 153 | Protein_2 | FlmC family protein | - |
| K4F91_RS26220 (K4F91_26220) | 2475..2594 | + | 120 | WP_229002406.1 | Hok/Gef family protein | - |
| K4F91_RS26225 (K4F91_26225) | 2744..3340 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| K4F91_RS26230 (K4F91_26230) | 3358..3642 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| K4F91_RS26235 (K4F91_26235) | 3716..4381 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| K4F91_RS26240 (K4F91_26240) | 4979..5308 | + | 330 | WP_000855121.1 | hypothetical protein | - |
| K4F91_RS26245 (K4F91_26245) | 5889..6212 | + | 324 | WP_000427402.1 | hypothetical protein | - |
| K4F91_RS26250 (K4F91_26250) | 6253..6462 | + | 210 | WP_000866037.1 | hypothetical protein | - |
| K4F91_RS26255 (K4F91_26255) | 6560..6784 | + | 225 | WP_000814383.1 | hypothetical protein | - |
| K4F91_RS26260 (K4F91_26260) | 6836..7096 | + | 261 | WP_000702245.1 | hypothetical protein | Toxin |
| K4F91_RS26265 (K4F91_26265) | 7086..7337 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| K4F91_RS26270 (K4F91_26270) | 7887..8165 | + | 279 | WP_000545937.1 | hypothetical protein | - |
| K4F91_RS26930 | 8552..8995 | - | 444 | WP_000192626.1 | hypothetical protein | - |
| K4F91_RS26280 (K4F91_26280) | 9292..9474 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| K4F91_RS26285 (K4F91_26285) | 9499..9936 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| K4F91_RS26290 (K4F91_26290) | 10066..10386 | - | 321 | WP_001401701.1 | hypothetical protein | - |
| K4F91_RS26295 (K4F91_26295) | 10720..10898 | - | 179 | Protein_18 | hypothetical protein | - |
| K4F91_RS26300 (K4F91_26300) | 10900..11103 | - | 204 | WP_000224735.1 | hypothetical protein | - |
| K4F91_RS26935 | 11424..11546 | - | 123 | Protein_20 | hypothetical protein | - |
| K4F91_RS26310 (K4F91_26310) | 11566..12273 | - | 708 | WP_000108795.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..63009 | 63009 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9818.23 Da Isoelectric Point: 9.5163
>T212727 WP_000702245.1 NZ_CP081196:6836-7096 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEEAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEEAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T212727 NZ_CP107340:2792-3058 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT212727 WP_001132407.1 NZ_CP081196:7086-7337 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT212727 NZ_CP107340:2584-2808 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|