Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4377114..4377709 Replicon chromosome
Accession NZ_CP081192
Organism Escherichia coli strain EC1722-1

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag K4F91_RS21180 Protein ID WP_000239579.1
Coordinates 4377114..4377464 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag K4F91_RS21185 Protein ID WP_001223208.1
Coordinates 4377458..4377709 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F91_RS21160 (4372390) 4372390..4373412 - 1023 WP_001339490.1 ABC transporter permease -
K4F91_RS21165 (4373426) 4373426..4374928 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
K4F91_RS21170 (4375238) 4375238..4376194 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
K4F91_RS21175 (4376504) 4376504..4377034 + 531 WP_000055072.1 inorganic diphosphatase -
K4F91_RS21180 (4377114) 4377114..4377464 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
K4F91_RS21185 (4377458) 4377458..4377709 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
K4F91_RS21190 (4377922) 4377922..4378263 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
K4F91_RS21195 (4378266) 4378266..4382045 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T212714 WP_000239579.1 NZ_CP081192:c4377464-4377114 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T212714 NZ_CP107334:2009758-2009860 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT212714 WP_001223208.1 NZ_CP081192:c4377709-4377458 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT212714 NZ_CP107334:c2009867-2009722 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References