Detailed information of TA system TA212693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 1772..2319
• Replicon: plasmid unnamed1
• Accession: NZ_CP081190
• Organism: Salmonella enterica strain sg1722-2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G7QEJ9
• Locus tag: K4F90_RS24060
• Protein ID: WP_001384452.1
• Coordinates: 2041..2319 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A723YP93
• Locus tag: K4F90_RS24055
• Protein ID: WP_021559054.1
• Coordinates: 1772..2041 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4F90_RS24045 (1)	1..858	+	858	WP_000131006.1	incFII family plasmid replication initiator RepA	-
K4F90_RS24050 (1559)	1559..1717	+	159	WP_072649723.1	hypothetical protein	-
K4F90_RS24055 (1772)	1772..2041	+	270	WP_021559054.1	type II toxin-antitoxin system antitoxin YacA	Antitoxin
K4F90_RS24060 (2041)	2041..2319	+	279	WP_001384452.1	type II toxin-antitoxin system toxin YacB	Toxin
K4F90_RS24065 (2445)	2445..3149	-	705	WP_001067858.1	IS6-like element IS26 family transposase	-
K4F90_RS24070 (3212)	3212..3811	-	600	Protein_6	ISL3-like element ISKox3 family transposase	-
K4F90_RS24075 (3913)	3913..4152	+	240	WP_001549892.1	hypothetical protein	-
K4F90_RS24080 (4155)	4155..4511	+	357	WP_004199403.1	hypothetical protein	-
K4F90_RS24085 (4545)	4545..5249	-	705	WP_001067855.1	IS6-like element IS26 family transposase	-
K4F90_RS24090 (5308)	5308..5442	+	135	WP_023408307.1	divalent cation tolerance protein CutA	-
K4F90_RS24095 (5447)	5447..5821	+	375	Protein_11	protein-disulfide reductase DsbD family protein	-
K4F90_RS24100 (5921)	5921..6478	+	558	Protein_12	twin-arginine translocation (TAT) pathway signal sequence domain protein	-
K4F90_RS24105 (6489)	6489..7127	-	639	WP_004201168.1	phosphoribosylanthranilate isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaNDM-1 / qnrS1	-	1..84884	84884

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10762.38 Da
• Isoelectric Point: 8.4615

>T212693 WP_001384452.1 NZ_CP081190:2041-2319 [Salmonella enterica]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Nucleotide

• Length: 279 bp

>T212693 NZ_CP107327:354089-354436 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10222.60 Da
• Isoelectric Point: 8.8735

>AT212693 WP_021559054.1 NZ_CP081190:1772-2041 [Salmonella enterica]
MAQINMSLRIDAELKDAFMAAAKSMDRNASQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT212693 NZ_CP107327:354436-354735 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: A0A829CL36

Antitoxin

• AlphaFold DB: A0A723YP93