Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4376102..4376883 Replicon chromosome
Accession NZ_CP081189
Organism Salmonella enterica strain sg1722-2

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K4F90_RS21325 Protein ID WP_000626099.1
Coordinates 4376102..4376593 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K4F90_RS21330 Protein ID WP_001110452.1
Coordinates 4376590..4376883 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F90_RS21285 (4371288) 4371288..4371530 - 243 WP_197603740.1 hypothetical protein -
K4F90_RS21290 (4371527) 4371527..4371883 - 357 WP_033567083.1 hypothetical protein -
K4F90_RS21295 (4371880) 4371880..4372752 - 873 WP_033567082.1 ParA family protein -
K4F90_RS21300 (4372943) 4372943..4373020 - 78 Protein_4171 helix-turn-helix domain-containing protein -
K4F90_RS21305 (4373111) 4373111..4373443 - 333 WP_001165471.1 MerR family transcriptional regulator -
K4F90_RS21310 (4373515) 4373515..4373892 + 378 WP_000916345.1 EthD family reductase -
K4F90_RS21315 (4374925) 4374925..4374999 + 75 Protein_4174 porin family protein -
K4F90_RS21320 (4375102) 4375102..4375854 + 753 WP_000842434.1 non-specific acid phosphatase -
K4F90_RS21325 (4376102) 4376102..4376593 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K4F90_RS21330 (4376590) 4376590..4376883 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K4F90_RS21335 (4377200) 4377200..4377421 + 222 WP_001576552.1 hypothetical protein -
K4F90_RS21340 (4377686) 4377686..4378561 + 876 WP_000921674.1 AraC family transcriptional regulator -
K4F90_RS21345 (4378558) 4378558..4378845 + 288 WP_001269916.1 transcriptional regulator RtsB -
K4F90_RS21350 (4378868) 4378868..4379083 + 216 WP_001595136.1 hypothetical protein -
K4F90_RS21355 (4379091) 4379091..4379360 + 270 WP_010989096.1 hypothetical protein -
K4F90_RS21360 (4379654) 4379654..4380559 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T212690 WP_000626099.1 NZ_CP081189:c4376593-4376102 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T212690 NZ_CP107325:1962-2276 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT212690 WP_001110452.1 NZ_CP081189:c4376883-4376590 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT212690 NZ_CP107325:1696-1974 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References