Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4376102..4376883 | Replicon | chromosome |
| Accession | NZ_CP081189 | ||
| Organism | Salmonella enterica strain sg1722-2 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | K4F90_RS21325 | Protein ID | WP_000626099.1 |
| Coordinates | 4376102..4376593 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | K4F90_RS21330 | Protein ID | WP_001110452.1 |
| Coordinates | 4376590..4376883 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K4F90_RS21285 (4371288) | 4371288..4371530 | - | 243 | WP_197603740.1 | hypothetical protein | - |
| K4F90_RS21290 (4371527) | 4371527..4371883 | - | 357 | WP_033567083.1 | hypothetical protein | - |
| K4F90_RS21295 (4371880) | 4371880..4372752 | - | 873 | WP_033567082.1 | ParA family protein | - |
| K4F90_RS21300 (4372943) | 4372943..4373020 | - | 78 | Protein_4171 | helix-turn-helix domain-containing protein | - |
| K4F90_RS21305 (4373111) | 4373111..4373443 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| K4F90_RS21310 (4373515) | 4373515..4373892 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| K4F90_RS21315 (4374925) | 4374925..4374999 | + | 75 | Protein_4174 | porin family protein | - |
| K4F90_RS21320 (4375102) | 4375102..4375854 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| K4F90_RS21325 (4376102) | 4376102..4376593 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| K4F90_RS21330 (4376590) | 4376590..4376883 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| K4F90_RS21335 (4377200) | 4377200..4377421 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| K4F90_RS21340 (4377686) | 4377686..4378561 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| K4F90_RS21345 (4378558) | 4378558..4378845 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| K4F90_RS21350 (4378868) | 4378868..4379083 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| K4F90_RS21355 (4379091) | 4379091..4379360 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| K4F90_RS21360 (4379654) | 4379654..4380559 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T212690 WP_000626099.1 NZ_CP081189:c4376593-4376102 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T212690 NZ_CP107325:1962-2276 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT212690 WP_001110452.1 NZ_CP081189:c4376883-4376590 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT212690 NZ_CP107325:1696-1974 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|