Detailed information of TA system TA021269

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1211631..1212190
• Replicon: chromosome
• Accession: NC_007484
• Organism: Nitrosococcus oceani ATCC 19707

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: NOC_RS16760
• Protein ID: WP_011330561.1
• Coordinates: 1211631..1211861 (+)
• Length: 77 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q3JC32
• Locus tag: NOC_RS06045
• Protein ID: WP_002809907.1
• Coordinates: 1211858..1212190 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NOC_RS06005	1207324..1208133	+	810	WP_002808885.1	hypothetical protein	-
NOC_RS06010	1208230..1208565	+	336	WP_002808871.1	hypothetical protein	-
NOC_RS06015	1208589..1208870	+	282	WP_011330557.1	BrnT family toxin	-
NOC_RS06025	1209395..1209682	+	288	WP_011330558.1	type II toxin-antitoxin system RelE/ParE family toxin	-
NOC_RS06030	1209693..1210011	+	319	Protein_1163	HigA family addiction module antidote protein	-
NOC_RS06035	1210208..1210540	-	333	WP_197538949.1	DUF768 domain-containing protein	-
NOC_RS16755	1210742..1210906	+	165	WP_147094471.1	tetratricopeptide repeat protein	-
NOC_RS06040	1211146..1211400	+	255	WP_011330560.1	type II toxin-antitoxin system HicB family antitoxin	-
NOC_RS16760	1211631..1211861	+	231	WP_011330561.1	type II toxin-antitoxin system HicA family toxin	Toxin
NOC_RS06045	1211858..1212190	+	333	WP_002809907.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
NOC_RS06050	1212510..1212854	+	345	WP_002811400.1	hypothetical protein	-
NOC_RS06055	1212992..1213435	-	444	WP_002810021.1	isoprenylcysteine carboxylmethyltransferase family protein	-
NOC_RS06060	1213557..1213934	-	378	WP_002810838.1	YbaN family protein	-
NOC_RS06065	1214141..1215463	+	1323	WP_002811653.1	glycerophosphoryl diester phosphodiesterase	-
NOC_RS06070	1215603..1217048	-	1446	WP_002809517.1	NADH-quinone oxidoreductase subunit N	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (15-66)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 77 a.a.
• Molecular weight: 8441.57 Da
• Isoelectric Point: 6.2139

>T21269 WP_011330561.1 NC_007484:1211631-1211861 [Nitrosococcus oceani ATCC 19707]
MERIFARPTSGTIPWSDIESLFVSLGADVSERAGSRVAVVLFGEVKVFHRPHPSPDTDKGAVNSIREWLDLHEVKP

Nucleotide

• Length: 231 bp

>T21269 NC_007484:1211631-1211861 [Nitrosococcus oceani ATCC 19707]
TTGGAAAGGATATTTGCTCGCCCTACTAGTGGAACTATTCCCTGGTCCGATATTGAGTCACTTTTTGTGTCACTCGGCGC
TGATGTGTCCGAGCGGGCAGGATCCCGAGTAGCAGTGGTTTTATTTGGCGAAGTCAAAGTTTTTCATCGTCCTCATCCTT
CACCAGACACGGATAAAGGCGCAGTTAATAGCATACGAGAATGGCTAGATTTACACGAGGTGAAACCATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12332.03 Da
• Isoelectric Point: 4.7872

>AT21269 WP_002809907.1 NC_007484:1211858-1212190 [Nitrosococcus oceani ATCC 19707]
MNVLEVDGFKAKIEFDPDLDLFRGEILGLNGSADFYGKSPASLRKEFKNSLKVFLEVCEEKGIEPTKEFSGKFNLRIPPR
LHSEISAKAAASNKSINQWVVEVLEESVNE

Nucleotide

• Length: 333 bp

>AT21269 NC_007484:1211858-1212190 [Nitrosococcus oceani ATCC 19707]
ATGAATGTTTTAGAAGTTGACGGCTTTAAAGCAAAAATTGAGTTCGACCCTGATCTTGATCTTTTTCGGGGCGAGATACT
TGGATTGAATGGCAGTGCTGATTTCTATGGGAAAAGCCCGGCAAGTTTACGAAAAGAGTTTAAAAACTCGCTAAAAGTAT
TTCTGGAAGTTTGTGAGGAAAAAGGTATAGAGCCCACAAAAGAATTTTCAGGTAAGTTTAACTTAAGAATTCCACCCAGA
TTACACAGTGAAATTTCGGCTAAGGCGGCCGCATCGAACAAGAGTATCAATCAATGGGTGGTCGAGGTTTTGGAAGAGTC
TGTAAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E2Z2K7