Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4166024..4166540 Replicon chromosome
Accession NZ_CP081189
Organism Salmonella enterica strain sg1722-2

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag K4F90_RS20220 Protein ID WP_000220578.1
Coordinates 4166024..4166308 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag K4F90_RS20225 Protein ID WP_000212724.1
Coordinates 4166298..4166540 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F90_RS20205 (4161236) 4161236..4162888 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
K4F90_RS20210 (4163297) 4163297..4165435 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
K4F90_RS20215 (4165556) 4165556..4166020 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K4F90_RS20220 (4166024) 4166024..4166308 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K4F90_RS20225 (4166298) 4166298..4166540 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K4F90_RS20230 (4166618) 4166618..4168531 - 1914 WP_001212137.1 BglG family transcription antiterminator -
K4F90_RS20235 (4168548) 4168548..4169288 - 741 WP_000779263.1 KDGP aldolase family protein -
K4F90_RS20240 (4169285) 4169285..4170403 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
K4F90_RS20245 (4170387) 4170387..4171520 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T212689 WP_000220578.1 NZ_CP081189:c4166308-4166024 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T212689 NZ_CP107322:c68218-68069 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT212689 WP_000212724.1 NZ_CP081189:c4166540-4166298 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT212689 NZ_CP107322:68263-68322 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References