Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3452850..3453470 Replicon chromosome
Accession NZ_CP081189
Organism Salmonella enterica strain sg1722-2

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag K4F90_RS16945 Protein ID WP_001280991.1
Coordinates 3453252..3453470 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag K4F90_RS16940 Protein ID WP_000344807.1
Coordinates 3452850..3453224 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F90_RS16930 (3447989) 3447989..3449182 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K4F90_RS16935 (3449205) 3449205..3452354 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
K4F90_RS16940 (3452850) 3452850..3453224 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
K4F90_RS16945 (3453252) 3453252..3453470 + 219 WP_001280991.1 HHA domain-containing protein Toxin
K4F90_RS16950 (3453649) 3453649..3454200 + 552 WP_001278792.1 maltose O-acetyltransferase -
K4F90_RS16955 (3454317) 3454317..3454787 + 471 WP_000136181.1 YlaC family protein -
K4F90_RS16960 (3454843) 3454843..3454983 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
K4F90_RS16965 (3454989) 3454989..3455249 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
K4F90_RS16970 (3455474) 3455474..3457024 + 1551 WP_000213139.1 EAL domain-containing protein -
K4F90_RS16980 (3457255) 3457255..3457644 + 390 WP_000961285.1 MGMT family protein -
K4F90_RS16985 (3457677) 3457677..3458246 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T212684 WP_001280991.1 NZ_CP081189:3453252-3453470 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T212684 NZ_CP107320:c5364457-5364074 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT212684 WP_000344807.1 NZ_CP081189:3452850-3453224 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT212684 NZ_CP107320:c5364699-5364457 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References