Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870309..870969 Replicon chromosome
Accession NZ_CP081189
Organism Salmonella enterica strain sg1722-2

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag K4F90_RS04225 Protein ID WP_000244756.1
Coordinates 870556..870969 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag K4F90_RS04220 Protein ID WP_000351186.1
Coordinates 870309..870575 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F90_RS04200 (866237) 866237..867670 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
K4F90_RS04205 (867829) 867829..868140 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
K4F90_RS04210 (868304) 868304..868963 + 660 WP_000250289.1 hemolysin III family protein -
K4F90_RS04215 (869079) 869079..870059 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
K4F90_RS04220 (870309) 870309..870575 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
K4F90_RS04225 (870556) 870556..870969 + 414 WP_000244756.1 protein YgfX Toxin
K4F90_RS04230 (871022) 871022..871543 - 522 WP_001055885.1 flavodoxin FldB -
K4F90_RS04235 (871656) 871656..872552 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
K4F90_RS04240 (872576) 872576..873289 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K4F90_RS04245 (873295) 873295..875028 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T212672 WP_000244756.1 NZ_CP081189:870556-870969 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T212672 NZ_CP107318:1962-2276 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT212672 WP_000351186.1 NZ_CP081189:870309-870575 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT212672 NZ_CP107318:1696-1974 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References