Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206530..207290 Replicon chromosome
Accession NZ_CP081189
Organism Salmonella enterica strain sg1722-2

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag K4F90_RS00965 Protein ID WP_000533909.1
Coordinates 206805..207290 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag K4F90_RS00960 Protein ID WP_000965886.1
Coordinates 206530..206817 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F90_RS00935 (201825) 201825..202127 + 303 WP_000605590.1 YsaB family lipoprotein -
K4F90_RS00940 (202266) 202266..203177 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
K4F90_RS00945 (203187) 203187..205256 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
K4F90_RS00950 (205438) 205438..205713 + 276 Protein_189 IS3 family transposase -
K4F90_RS00955 (205885) 205885..206352 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
K4F90_RS00960 (206530) 206530..206817 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
K4F90_RS00965 (206805) 206805..207290 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
K4F90_RS00970 (207662) 207662..208201 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
K4F90_RS00975 (208375) 208375..208587 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
K4F90_RS00980 (208876) 208876..209166 - 291 WP_000455790.1 HTH-type transcriptional regulator -
K4F90_RS00985 (209605) 209605..210315 + 711 WP_000190524.1 DUF3053 domain-containing protein -
K4F90_RS00990 (210365) 210365..211339 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
K4F90_RS00995 (211558) 211558..212220 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T212669 WP_000533909.1 NZ_CP081189:206805-207290 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T212669 NZ_CP107314:c3395-2925 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT212669 WP_000965886.1 NZ_CP081189:206530-206817 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT212669 NZ_CP107314:c3835-3392 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References