Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4414180..4414961 | Replicon | chromosome |
| Accession | NZ_CP081187 | ||
| Organism | Salmonella enterica strain sg1722-1 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | K4F82_RS21475 | Protein ID | WP_000626099.1 |
| Coordinates | 4414180..4414671 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | K4F82_RS21480 | Protein ID | WP_001110452.1 |
| Coordinates | 4414668..4414961 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K4F82_RS21435 (4409366) | 4409366..4409608 | - | 243 | WP_197603740.1 | hypothetical protein | - |
| K4F82_RS21440 (4409605) | 4409605..4409961 | - | 357 | WP_033567083.1 | hypothetical protein | - |
| K4F82_RS21445 (4409958) | 4409958..4410830 | - | 873 | WP_033567082.1 | ParA family protein | - |
| K4F82_RS21450 (4411021) | 4411021..4411098 | - | 78 | Protein_4211 | helix-turn-helix domain-containing protein | - |
| K4F82_RS21455 (4411189) | 4411189..4411521 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| K4F82_RS21460 (4411593) | 4411593..4411970 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| K4F82_RS21465 (4413003) | 4413003..4413077 | + | 75 | Protein_4214 | porin family protein | - |
| K4F82_RS21470 (4413180) | 4413180..4413932 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| K4F82_RS21475 (4414180) | 4414180..4414671 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| K4F82_RS21480 (4414668) | 4414668..4414961 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| K4F82_RS21485 (4415278) | 4415278..4415499 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| K4F82_RS21490 (4415764) | 4415764..4416639 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| K4F82_RS21495 (4416636) | 4416636..4416923 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| K4F82_RS21500 (4416946) | 4416946..4417161 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| K4F82_RS21505 (4417169) | 4417169..4417438 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| K4F82_RS21510 (4417732) | 4417732..4418637 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T212666 WP_000626099.1 NZ_CP081187:c4414671-4414180 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T212666 NZ_CP107312:4749909-4750011 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT212666 WP_001110452.1 NZ_CP081187:c4414961-4414668 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT212666 NZ_CP107312:c4750018-4749873 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|