Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4204102..4204618 Replicon chromosome
Accession NZ_CP081187
Organism Salmonella enterica strain sg1722-1

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag K4F82_RS20370 Protein ID WP_000220578.1
Coordinates 4204102..4204386 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag K4F82_RS20375 Protein ID WP_000212724.1
Coordinates 4204376..4204618 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4F82_RS20355 (4199314) 4199314..4200966 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
K4F82_RS20360 (4201375) 4201375..4203513 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
K4F82_RS20365 (4203634) 4203634..4204098 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K4F82_RS20370 (4204102) 4204102..4204386 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K4F82_RS20375 (4204376) 4204376..4204618 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K4F82_RS20380 (4204696) 4204696..4206609 - 1914 WP_001212137.1 BglG family transcription antiterminator -
K4F82_RS20385 (4206626) 4206626..4207366 - 741 WP_000779263.1 KDGP aldolase family protein -
K4F82_RS20390 (4207363) 4207363..4208481 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
K4F82_RS20395 (4208465) 4208465..4209598 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T212665 WP_000220578.1 NZ_CP081187:c4204386-4204102 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T212665 NZ_CP107312:3630636-3631043 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT212665 WP_000212724.1 NZ_CP081187:c4204618-4204376 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT212665 NZ_CP107312:3630389-3630655 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References