Detailed information of TA system TA021266

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 477642..478276
• Replicon: chromosome
• Accession: NC_007484
• Organism: Nitrosococcus oceani ATCC 19707

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: NOC_RS02460
• Protein ID: WP_002812854.1
• Coordinates: 477642..478046 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q3JDY1
• Locus tag: NOC_RS02465
• Protein ID: WP_002812508.1
• Coordinates: 478046..478276 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NOC_RS02425	472856..473125	-	270	WP_002813981.1	type II toxin-antitoxin system RelE/ParE family toxin	-
NOC_RS02430	473128..473325	-	198	WP_002813417.1	hypothetical protein	-
NOC_RS02435	473378..474433	-	1056	WP_011330339.1	NAD(P)-dependent alcohol dehydrogenase	-
NOC_RS02440	474660..474935	-	276	WP_002813598.1	amphi-Trp domain-containing protein	-
NOC_RS02445	475351..475644	-	294	WP_036497897.1	HigA family addiction module antidote protein	-
NOC_RS02450	475644..475922	-	279	WP_011330341.1	type II toxin-antitoxin system RelE/ParE family toxin	-
NOC_RS02455	476041..477645	-	1605	WP_011330342.1	type I restriction-modification system subunit M	-
NOC_RS02460	477642..478046	-	405	WP_002812854.1	tRNA(fMet)-specific endonuclease VapC	Toxin
NOC_RS02465	478046..478276	-	231	WP_002812508.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
NOC_RS02470	478400..479554	-	1155	WP_011330343.1	transposase	-
NOC_RS02475	479590..479742	+	153	WP_036497902.1	CopG family transcriptional regulator	-
NOC_RS17235	479823..479963	-	141	WP_011330344.1	hypothetical protein	-
NOC_RS02480	479999..480289	-	291	WP_002813622.1	type II toxin-antitoxin system RelE/ParE family toxin	-
NOC_RS02485	480279..480521	-	243	WP_002812536.1	CopG family ribbon-helix-helix protein	-
NOC_RS02490	480607..481899	-	1293	WP_197538940.1	restriction endonuclease subunit S	-
NOC_RS02495	481904..482395	-	492	WP_002813653.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	473378..484992	11614

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15110.35 Da
• Isoelectric Point: 8.4988

>T21266 WP_002812854.1 NC_007484:c478046-477642 [Nitrosococcus oceani ATCC 19707]
MLRYLLDTNICIFTIKNRPARVRERFKQFADQLCISSVTWMELVYSVERSANPQHNLAIAEGLAARLSVLDYDVEAASHT
GQIRAELARRGTPIGPYDQMIAGQARSRGLVVVTNNTCEFARVPGLRCEDWTKP

Nucleotide

• Length: 405 bp

>T21266 NC_007484:c478046-477642 [Nitrosococcus oceani ATCC 19707]
ATGCTGCGCTACTTGCTGGATACCAACATCTGCATTTTCACCATTAAGAACCGACCGGCGCGGGTTCGTGAGCGCTTCAA
GCAGTTTGCCGATCAGTTGTGCATCAGCAGCGTGACCTGGATGGAGCTGGTGTATAGCGTGGAGCGCTCAGCCAACCCGC
AACACAATCTGGCGATTGCGGAGGGGCTGGCGGCGCGTCTCAGCGTGCTGGATTACGACGTCGAAGCGGCCAGCCACACG
GGGCAGATCCGTGCTGAACTTGCGCGCCGTGGAACACCGATAGGGCCGTATGATCAAATGATAGCCGGACAGGCGCGCAG
CCGTGGGCTGGTTGTGGTCACCAACAACACGTGCGAGTTCGCACGCGTTCCCGGCCTGCGATGCGAGGACTGGACAAAGC
CATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8530.51 Da
• Isoelectric Point: 4.2792

>AT21266 WP_002812508.1 NC_007484:c478276-478046 [Nitrosococcus oceani ATCC 19707]
MEHTKLFKSNRSQAVRLPKAVAFPADVTDVDIVAIGRARLITPAGDAWDVWFDGPAVSPDFMDDRDQPDEQEREAF

Nucleotide

• Length: 231 bp

>AT21266 NC_007484:c478276-478046 [Nitrosococcus oceani ATCC 19707]
ATGGAACATACCAAACTGTTCAAGAGTAACCGCAGCCAGGCCGTGCGGCTGCCCAAGGCGGTGGCCTTCCCGGCGGACGT
GACGGATGTGGATATCGTGGCCATCGGGCGCGCGCGGCTGATTACCCCCGCCGGTGACGCTTGGGACGTCTGGTTTGATG
GCCCGGCGGTCAGCCCAGACTTCATGGACGATCGTGACCAGCCTGACGAGCAGGAACGCGAGGCATTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E2ZQ94